Category Archives: Uncategorized

Toward the Development of Epigenome Editing-Based Therapeutics: Potentials and Challenges Posted on January 7, 2024 by admin

Abstract:  The advancement in epigenetics research over the past several decades has led to the potential application of epigenome-editing technologies for the treatment of various diseases. In particular, epigenome editing is potentially useful in the treatment of genetic and other … Continue reading →

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Physical activity is associated with slower epigenetic ageing Posted on January 6, 2024 by admin

Epigenetic ageing, i.e., age‐associated changes in DNA methylation patterns, is a sensitive marker of biological ageing, a major determinant of morbidity and functional decline. We examined the association of physical activity with epigenetic ageing and the role of immune function … Continue reading →

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Exercise-related physical activity is associated with increased brain volumes, indicating potential neuroprotective effects Posted on January 2, 2024 by admin

Abstract: Background:The potential neuroprotective effects of regular physical activity on brain structure are unclear, despite links between activity and reduced dementia risk. Objective:To investigate the relationships between regular moderate to vigorous physical activity and quantified brain volumes on magnetic resonance … Continue reading →

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COVID-19 as a polymorphic inflammatory spectrum of diseases: a review with focus on the brain Posted on January 1, 2024 by admin

https://pubmed.ncbi.nlm.nih.gov/36861428/

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Remembering Professor Brian Leonard and his contributions to the Institute of Brain Medicine Posted on December 31, 2023 by admin
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In Memory: Professor Brian Leonard 1936-2023 Posted on December 30, 2023 by admin
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Sigma-1 receptor activation mediates the sustained antidepressant effect of ketamine in mice via increasing BDNF levels Posted on December 25, 2023 by admin

Abstract: Sigma-1 receptor (S1R) is a unique multi-tasking chaperone protein in the endoplasmic reticulum. Since S1R agonists exhibit potent antidepressant-like activity, S1R has become a novel target for antidepression therapy. With a rapid and sustained antidepressant effect, ketamine may also … Continue reading →

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The Neurobiology of Stress: Vulnerability, Resilience, and Major Depression Posted on December 15, 2023 by admin

https://www.pnas.org/topic/558 INTRODUCTIONNOVEMBER 27, 2023 The neurobiology of stress: Vulnerability, resilience, and major depression Huda Akil, Eric J. Nestler, RESEARCH ARTICLENOVEMBER 27, 2023 Transcriptional signatures of early-life stress and antidepressant treatment efficacy Sero Toriano Parel, Shannon N. Bennett, […] Catherine Jensen … Continue reading →

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Lithium treatment for an animal model of autism spectrum disorder Posted on December 8, 2023 by admin

Abstract Background: Tbr1 encodes a T-box transcription factor and is considered a high confidence autism spectrum disorder (ASD) gene. Tbr1 is expressed in the postmitotic excitatory neurons of the deep neocortical layers 5 and 6. Postnatally and neonatally, Tbr1 conditional … Continue reading →

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Blocking SIG1R Along with Low Cadmium Exposure Display Anti-cancer Qualities in Both MCF7 and MDA-MB-231 Cells Posted on December 2, 2023 by admin

Abstract: Sigma-1 receptor (SIG1R) is a chaperone that modulates inositol 1,4,5-trisphosphate receptor type1 (IP3R1) calcium (Ca2+) channels on the endoplasmic reticulum. Therefore, SIG1R functions as an indirect regulator of Ca2+ and acts as an apoptosis modulator. Increased expression of SIG1R is … Continue reading →

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