Monthly Archives: November 2015

This report demonstrates that passive immunotherapy with amyloid-β(Aβ)-targeting antibodies in Alzheimer transgenic mice was both ineffective in treating neuronal dysfunction, and actually worsened it. Administration of two different monoclonal antibodies resulted in significantly increased numbers of pathologically hyperactive neurons and … Continue reading

Posted in Uncategorized | Comments Off on Decreased amyloid-β and associated increase in neuronal hyperactivity by immunotherapy: anti-Aβ immunotherapies in Alzheimer models

Bipolar disorder is a complex neuropsychiatric disorder that is characterized by intermittent episodes of mania and depression; without treatment, approximately 15% of patients commit suicide. It has been ranked by the World Health Organization as a top disorder of morbidity … Continue reading

Posted in Uncategorized | Comments Off on Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder

Smoking tobacco is a well-established risk factor for multiple sclerosis, a chronic inflammatory disorder of the central nervous system characterized by flare-ups and remissions and typically followed by a secondary progressive course. The purpose of this study was to determine … Continue reading

Posted in Uncategorized | Comments Off on Effect of Smoking Cessation on Multiple Sclerosis Prognosis

Top-down prefrontal cortex inputs to the hippocampus have been hypothesized to be important in memory consolidation, retrieval, and the pathophysiology of major psychiatric diseases; however, no such direct projections have been identified and functionally described. Here the authors report the … Continue reading

Posted in Uncategorized | Comments Off on Projections from neocortex mediate top-down control of memory retrieval