Summary: “Osteoarthritis (OA) is a degenerative joint disease and the most common form of arthritis globally, which is a leading cause of disability among the elderly population. The typical symptoms of OA include pain and stiffness in the affected joints. The current treatment strategies for OA include regular exercise, acupuncture, and massage. Patients with severe OA have to undergo surgery, such as joint replacement. Although the etiology of OA remains not fully understood, it is well recognized that the pathogenesis and progression of OA are closely associated with abnormal immune responses in the cartilage microenvironment (1). Apart from regulatory proteins, emerging evidence has underscored the crucial roles of immunoregulatory metabolites in various immune disorders (2). Compared to traditional medications, natural metabolites, many of which are derived from our daily diet, usually have advantages in terms of higher availability, proven safety, and lower costs. Therefore, the diet-based intervention of immunological diseases has been attracting increasingly more attention in recent years. However, the metabolic alterations in the cartilage microenvironment of OA patients and their potential effects on OA pathogenesis remain largely unexplored to date. Herein, we report a unique, anti-OA role of vitamin B1 (VB1), and the underlying mechanism was further explored.”
Shen S, Liang Y, Zhao Y, Hu Z, Huang Y, Wu Y, Liu Y, Fan S, Wang Q, Xiao P. Dietary supplementation of vitamin B1 prevents the pathogenesis of osteoarthritis. Proc Natl Acad Sci U S A. 2024 Jul 23;121(30):e2408160121. doi: 10.1073/pnas.2408160121. Epub 2024 Jul 18. PMID: 39024114.
