Monthly Archives: April 2014

According to the authors of this paper, meta-analyses of randomized trial data suggest that suicidal behavior is twice as likely when children and young adults are randomized to antidepressants compared with when they are randomized to placebo. In this report, … Continue reading

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Although it has long been recognized that many individuals with attention deficit hyperactivity disorder (ADHD) also have difficulties with emotion regulation, no consensus has been reached on how to conceptualize this clinically challenging domain. The authors of this report examined … Continue reading

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Multiple sclerosis is one of the most frequent chronic inflammatory diseases of the CNS. Progress has been made in understanding and moderating the acute inflammatory components, but the mechanisms of the concomitant neurodegeneration are still not understood. Clinical outcome is … Continue reading

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The APOE4 allele is the strongest genetic risk factor for sporadic Alzheimer’s disease and case-control studies suggest that the APOE4 link is stronger in women. Altmann and colleagues ¬†examined the APOE4-by-sex interaction in conversion risk and cerebrospinal fluid biomarker levels. … Continue reading

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Genetic variations in catechol-O-methyltransferase (COMT) modulate cortical dopamine levels and have been associated with various behavioral effects in humans and mice. Recent data also show gender differences. In this report, Sannino and colleagues report that genetically driven reduction in COMT … Continue reading

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Clear evidence supports a genetic basis for substance abuse disorders. Yet, the search to identify individual gene contributions has been unsuccessful. Here, Belcher and colleagues argue for the study of endophenotypes within the frame of individual differences, and identify three … Continue reading

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