Monthly Archives: October 2023

Stress, Heritability, and Genetic Factors Influencing Depression, PTSD, and Suicidal Behavior Posted on October 30, 2023 by admin

https://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.20230631

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Fungal microbiota sustains lasting immune activation of neutrophils and their progenitors in severe COVID-19 Posted on October 24, 2023 by admin

Abstract:  Gastrointestinal fungal dysbiosis is a hallmark of several diseases marked by systemic immune activation. Whether persistent pathobiont colonization during immune alterations and impaired gut barrier function has a durable impact on host immunity is unknown. We found that elevated … Continue reading →

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Multi-omics analysis of mucosal and systemic immunity to SARS-CoV-2 after birth Posted on October 19, 2023 by admin

Highlights • Infants and young children mount antibody responses that are durable for up to 300 days • Atypical innate response in blood: no inflammatory markers; high IFNα and chemokines • Robust upper respiratory tract antiviral and inflammatory responses • Single-cell … Continue reading →

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Differential response to SSRI versus Placebo and distinct neural signatures among data-driven subgroups of patients with major depressive disorder Posted on October 18, 2023 by admin

Abstract Objective: To identify data-driven subgroups in Major Depressive Disorder (MDD) in order to elucidate underlying neural correlates and determine if these subgroups have utility in predicting response to antidepressant versus placebo. Methods: Using 27 clinical measures at baseline of … Continue reading →

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Science fair notes for supervisors of student projects….Part 2. Posted on October 17, 2023 by admin
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Science fair notes for supervisors of student projects….Part 1. Posted on October 14, 2023 by admin

 

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Epigenetic signatures in antidepressant treatment response: a methylome-wide association study in the EMC trial Posted on October 10, 2023 by admin

Engelmann, J., Zillich, L., Frank, J. et al. Epigenetic signatures in antidepressant treatment response: a methylome-wide association study in the EMC trial. Transl Psychiatry 12, 268 (2022). https://doi.org/10.1038/s41398-022-02032-7

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Hormonal gatekeeping via the blood-brain barrier governs caste-specific behavior in ants Posted on October 5, 2023 by admin

Highlights • Single-cell RNA-seq identifies hormone-degrading esterase CfJhe localized to ant BBB • CfJhe expression is high in non-foraging Major-worker BBB cells leading to low JH3 • Ectopic expression of CfJhe in fly leads to loss of foraging-like behavior • … Continue reading →

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