Monthly Archives: February 2019

Abstract: “Sleep is integral to life. Although insufficient or disrupted sleep increases the risk of multiple pathological conditions, including cardiovascular disease, we know little about the cellular and molecular mechanisms by which sleep maintains cardiovascular health. Here we report that … Continue reading

Posted in Uncategorized | Comments Off on Sleep modulates haematopoiesis and protects against atherosclerosis

Summary: Sigma-1 receptors subdue systemic inflammation, which can be lethal, as in the case of septic shock. Mice lacking the endoplasmic reticulum sigma-1 receptor had exacerbated responses to LPS (lipopolysaccharides) or fecal slurry. The antidepressant fluvoxamine can bind sigma-1 and … Continue reading

Posted in Uncategorized | Comments Off on Antidepressant fluvoxamine lowers inflammatory cytokine production via sigma-1 receptor

Abstract: “Selective serotonin reuptake inhibitors (SSRIs) are the most prescribed antidepressants. They regulate serotonergic neurotransmission, but it remains unclear how altered serotonergic neurotransmission may contribute to the SSRI resistance observed in approximately 30% of major depressive disorder (MDD) patients. Patient stratification based on pharmacological responsiveness and the … Continue reading

Posted in Uncategorized | Comments Off on Serotonin-induced hyperactivity in SSRI-resistant major depressive disorder patient-derived neurons

Summary: “UNICEF estimates that there are approximately 8 million children worldwide who live in institutions. Institutional rearing often involves severe psychosocial neglect associated with suboptimal brain and behavioral development. This study uses data from the only existing longitudinal RCT of … Continue reading

Posted in Uncategorized | Comments Off on Long-term effects of institutional rearing, foster care, and brain activity on memory and executive functioning

Abstract “Internet technology offers psychiatrists new opportunities for remote interaction with patients. It also raises issues regarding therapeutic effectiveness, safety, technical problems and possibilities for overcoming them, and matters related to specific mental health problems such as autism. The case … Continue reading

Posted in Uncategorized | Comments Off on Telepsychiatry in Asperger’s syndrome