Monthly Archives: January 2018

“During evolution, individuals whose brains and bodies functioned well in a fasted state were successful in acquiring food, enabling their survival and reproduction. With fasting and extended exercise, liver glycogen stores are depleted and ketones are produced from adipose-cell-derived fatty … Continue reading

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Learning reflects the influence of experience on genetically determined circuitry, but little is known about how experience and genetics interact to determine learned phenotypes. Here, Mets and Brainard use vocal learning in songbirds to study genetic influences on learned behavior. … Continue reading

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ABSTRACT SUMMARY AND GOALS: To update the 2001 American Academy of Neurology (AAN) guideline on mild cognitive impairment (MCI). METHODS and RESULTS: The guideline panel systematically reviewed MCI prevalence, prognosis, and treatment articles according to AAN evidence classification criteria, and … Continue reading

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The BDNF mimetic compound 7,8-dihydroxyflavone (7,8-DHF), a potent small molecular TrkB agonist, displays prominent therapeutic efficacy against Alzheimer’s disease. However, 7,8-DHF has only modest oral bioavailability and a moderate pharmacokinetic profile. To alleviate these preclinical obstacles, the authors used a … Continue reading

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