Monthly Archives: January 2018

Bridging the divide: Interdisciplinary research into vulnerable populations in China Posted on January 25, 2018 by admin

http://www.sciencemag.org/collections/bridging-divide-interdisciplinary-research-vulnerable-populations-china Bridging the divide: Interdisciplinary research into vulnerable populations in China 29 DECEMBER 2017

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Intermittent metabolic switching, neuroplasticity and brain health Posted on January 21, 2018 by admin

“During evolution, individuals whose brains and bodies functioned well in a fasted state were successful in acquiring food, enabling their survival and reproduction. With fasting and extended exercise, liver glycogen stores are depleted and ketones are produced from adipose-cell-derived fatty … Continue reading →

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Genetic variation interacts with experience to determine interindividual differences in learning Posted on January 10, 2018 by admin

Learning reflects the influence of experience on genetically determined circuitry, but little is known about how experience and genetics interact to determine learned phenotypes. Here, Mets and Brainard use vocal learning in songbirds to study genetic influences on learned behavior. … Continue reading →

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Mild cognitive impairment: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology Posted on January 5, 2018 by admin

ABSTRACT SUMMARY AND GOALS: To update the 2001 American Academy of Neurology (AAN) guideline on mild cognitive impairment (MCI). METHODS and RESULTS: The guideline panel systematically reviewed MCI prevalence, prognosis, and treatment articles according to AAN evidence classification criteria, and … Continue reading →

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BDNF mimetic prodrug for treating Alzheimer’s disease Posted on January 3, 2018 by admin

The BDNF mimetic compound 7,8-dihydroxyflavone (7,8-DHF), a potent small molecular TrkB agonist, displays prominent therapeutic efficacy against Alzheimer’s disease. However, 7,8-DHF has only modest oral bioavailability and a moderate pharmacokinetic profile. To alleviate these preclinical obstacles, the authors used a … Continue reading →

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