Monthly Archives: November 2021

1-year outcomes in hospital survivors with COVID-19 Posted on November 25, 2021 by admin

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)01755-4/fulltext

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Safety and efficacy of fluvoxamine in COVID-19 ICU patients Posted on November 23, 2021 by admin

Abstract Fluvoxamine, an SSRI and sigma-1 receptor agonist, has so far shown promise in the prevention of COVID-19 progression as an early treatment option in 3 conducted trials. The aim of this study was to evaluate the safety and efficacy … Continue reading →

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Covid-19 related stroke: No preventative value of antithrombotic therapy Posted on November 21, 2021 by admin

Abbreviated Highlights: In several previously published studies, the incidence of Acute Ischemic Stroke ranged from 0.9% to 2.7% in those with COVID-19, …  One of the studies calculated a more than sevenfold greater risk of Acute Ischemic Stroke among patients … Continue reading →

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Rapid response to selective serotonin reuptake inhibitors in post-COVID depression Posted on November 17, 2021 by admin

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500775/

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In vitro and in vivo sigma 1 receptor imaging studies in different disease states Posted on November 15, 2021 by admin

Agha H, McCurdy CR. In vitro and in vivo sigma 1 receptor imaging studies in different disease states. RSC Med Chem. 2021 Oct 8;12(2):154-177. doi: 10.1039/d0md00186d. PMID: 34046607; PMCID: PMC8127618. https://pubmed.ncbi.nlm.nih.gov/34046607/

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Association of Alopecia Areata with increased Risk of Dementia Posted on November 6, 2021 by admin

Alopecia areata (AA) is an autoimmune disorder that usually results in unpredictable, patchy hair loss. It is associated with multiple comorbidities and shares a similar inflammatory signature with dementia. The great negative psychosocial impact of AA may result in poor … Continue reading →

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Brain-derived neurotrophic factor for high-throughput evaluation of selective Sigma-1 receptor ligands Posted on November 4, 2021 by admin

Abstract:  “The Sigma-1 receptor (S1R) is an endoplasmic reticulum (ER) chaperone protein that has been implicated in attenuating inflammatory stress-mediated brain injuries. Selective S1R agonists represent a new class of therapeutic agent for treating neuropsychiatric and neurodegenerative disorders, however, to … Continue reading →

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