Author Archives: admin

Abstract: “Cerebral blood flow is reduced early in Alzheimer’s disease (AD). Because most of the vascular resistance within the brain is in capillaries, this could reflect dysfunction of contractile pericytes on capillary walls. Here we used live and rapidly-fixed biopsied … Continue reading

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Abstract: “The past decade has seen a dramatic expansion of the field of prodromal Parkinson’s disease (PD). Ten years ago, there were only six known prodromal markers of disease, none of which had more than two studies documenting diagnostic value. … Continue reading

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Summary: “Some of the most effective new pharmaceutical drugs are highly complex biological molecules. To make such therapies less expensive and more broadly available, drug developers seek to fashion biosimilars — good-enough copies that can be produced at large scale.”  … Continue reading

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Abstract: “Multiple sclerosis (MS) is characterized by inflammatory insults that drive neuroaxonal injury. However, knowledge about neuron-intrinsic responses to inflammation is limited. By leveraging neuron-specific messenger RNA profiling, we found that neuroinflammation leads to induction and toxic accumulation of the synaptic … Continue reading

Posted in Uncategorized | Comments Off on Bassoon proteinopathy drives neurodegeneration in multiple sclerosis

Abstract:  “Mental health and well-being are consistently influenced-directly or indirectly-by multiple environmental exposures. In this review, we have attempted to address some of the most common exposures of the biophysical environment, with a goal of demonstrating how those factors interact … Continue reading

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Abstract: “Memory is coded by patterns of neural activity in distinct circuits. Therefore, it should be possible to reverse engineer a memory by artificially creating these patterns of activity in the absence of a sensory experience. In olfactory conditioning, an … Continue reading

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Abstract: “The neurobiological mechanisms underlying the induction and remission of depressive episodes over time are not well understood. Through repeated longitudinal imaging of medial prefrontal microcircuits in the living brain, we found that prefrontal spinogenesis plays a critical role in … Continue reading

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Abbreviated abstract: Children learn language more easily than adults, though when and why this ability declines have been obscure for a number of reasons. Studying a very large number of subjects, the authors  provide the first direct estimate of how grammar-learning ability … Continue reading

Posted in Uncategorized | Comments Off on A critical period for second language acquisition: Evidence from 2/3 million English speakers

Summary: Noninvasive delivery of alternating electrical currents to temporal and prefrontal brain regions improves working memory and reverses age-related changes in brain dynamics in the elderly, report Reinhart and Nguyen in Nature Neuroscience (22):820–827(2019). They also report a similar effect … Continue reading

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Summary: “Depression is a mental illness characterized by episodes of a sad, despondent mood and/or a loss of interest or pleasure. This pathology affects nearly 20% of the population in the United States, and treatments are limited. Indeed, in the … Continue reading

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