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Excerpts from article: “The observation that higher rates of schizophrenia and other nonaffective psychotic disorders are associated with city living is robustly replicated across epidemiologic studies conducted throughout Northern Europe and North America. The weight of this evidence, combined with exhaustive … Continue reading

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Abstract:  “Most people with bipolar disorder spend a significant percentage of their lifetime experiencing either subsyndromal depressive symptoms or major depressive episodes, which contribute greatly to the high levels of disability and mortality associated with the disorder. Despite the importance of bipolar depression, there are … Continue reading

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Abstract: “The discovery of the mechanisms underlying light-gated ion channels called channel rhodospins and the subsequent development of optogenetics illustrates how breakthroughs in science and technology can span multiple levels of scientific inquiry. Our knowledge of how channelrhodopsins work emerged … Continue reading

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Obsessive-compulsive disorder (OCD) is associated with increased mortality, but the causes of this increase are poorly understood. This study by Isomura and colleagues examined whether OCD is associated with increased risk of metabolic and cardiovascular complications. Subjects diagnosed with OCD (n = 25,415) were identified and studied … Continue reading

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Abstract: “Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute substantially to ADHD susceptibility, but no variants have been robustly associated with ADHD. We report a … Continue reading

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Dysregulation of the dopamine system is a well-established component of schizophrenia pathophysiology, with regional differences in dopamine targets thought to shape disease symptoms. Increased presynaptic striatal dopamine synthesis and release are among the most consistent findings in patients. These alterations … Continue reading

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Abstract: “Heart valve disease (HVD) is a complex entity made by different pathological processes that ultimately lead to the abnormal structure and disorganization of extracellular matrix proteins resulting to dysfunction of the leaflets. At its final evolutionary step, treatments are limited … Continue reading

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Abstract: “Strong evidence has emerged recently for the concept that herpes simplex virus type 1 (HSV1) is a major risk for Alzheimer’s disease. This concept proposes that latent HSV1 in brain of carriers of the type 4 allele of the … Continue reading

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Summary:  Light exerts a range of powerful biological effects beyond image vision, including effects on mood and learning. While the source of photic information affecting mood and cognitive functions is well established, via intrinsically photosensitive retinal ganglion cells (ipRGCs), the … Continue reading

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“…Immune cells normally pounce on intruding bacteria and viruses. But in multiple sclerosis (MS), immune cells target the nervous system instead. Now, researchers may have pinpointed a long-sought molecule called a self-antigen that provokes these attacks, pointing a way toward … Continue reading

Posted in Uncategorized | Comments Off on Elusive molecule that sparks multiple sclerosis may have been found