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Abstract: “Despite evidence for a role of the dopamine system in the pathophysiology of schizophrenia, there has not been substantial evidence that this disorder originates from a pathological change within the dopamine system itself. Current data from human imaging studies … Continue reading

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“The effects of neurodegenerative syndromes extend beyond cognitive function to involve key physiological processes, including eating and metabolism, autonomic nervous system function, sleep, and motor function. Changes in these physiological processes are present in several conditions, including frontotemporal dementia, amyotrophic … Continue reading

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This study shows that the number of mature neurons in the human amygdala increases from childhood into adulthood. The authors suggest that this trajectory may be due to the incorporation of immature neurons from the paralaminar nucleus in the ventral … Continue reading

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Bipolar disorder is considered to be a leading cause of global disability. Its biological basis is unknown, and its treatment is not optimal. Here, Harrison and colleagues review two recent areas of progress.” First, the discovery of risk genes and … Continue reading

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The current report analyzed mitochondrial complex I activity in bipolar disorder patients, schizophrenics, and control subjects and in the presence of antipsychotic and antidepressant medications. Complex I activity in the prefrontal cortex was decreased by 45% in schizophrenics compared to … Continue reading

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“Excessive dopamine neurotransmission underlies psychotic episodes as observed in patients with some types of bipolar disorder and schizophrenia. The dopaminergic hypothesis was postulated after the finding that antipsychotics were effective to halt increased dopamine tone. However, there is little evidence for dysfunction within … Continue reading

Posted in Uncategorized | Comments Off on Deletion of dopamine D2 receptors from parvalbumin interneurons causes schizophrenia-like phenotypes

The purpose of this study was to investigate whether greater cardiovascular fitness in midlife is associated with decreased dementia risk in women followed for 44 years. A population-based sample of 1,462 women 38 to 60 years of age was examined … Continue reading

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Patients surviving a stroke are at increased risk for subsequent cardiovascular events and accelerated atherosclerosis. Roth and colleagues now show that stroke exacerbates atherosclerosis progression via alarmin-mediated propagation of vascular inflammation. Recruitment of activated monocytes via the CC-chemokine ligand 2–CC-chemokine … Continue reading

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“New neurons continue to be generated in the subgranular zone of the dentate gyrus of the adult mammalian hippocampus. This process has been linked to learning and memory, stress and exercise, and is thought to be altered in neurological disease. In humans, … Continue reading

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This study examined the risks of myocardial infarction, stroke, peripheral artery disease, venous thromboembolism, atrial fibrillation, and heart failure in patients with migraine and in a general population comparison cohort. Higher risks were observed among patients with incident migraine than in the general population across most … Continue reading

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