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Abstract In this issue of Cell, Wei et al. show that the increased cardiovascular risks associated with cannabis use are mediated by proinflammatory cannabinoid 1 (CB1) receptor signaling, which can be ameliorated with the natural antioxidant agent genistein. Sakmar TP. … Continue reading

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Abstract: “The prevalence of autoimmune diseases (ADs) worldwide has rapidly increased over the past few decades. Thus, in addition to the classical risk factors for ADs, such as genetic polymorphisms, infections and smoking, environmental triggers have been considered. Recent sequencing-based … Continue reading

Posted in Uncategorized | Comments Off on The impact of the gut microbiome on extra-intestinal autoimmune diseases

Abstract: “The ongoing coronavirus disease 2019 (COVID-19) pandemic caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) accelerates the discovery of prophylactic and therapeutic drugs for persons infected with the virus. Drug repurposing for the COVID-19 pandemic has … Continue reading

Posted in Uncategorized | Comments Off on Mechanisms of action of fluvoxamine for COVID-19: a historical review

Abstract:  “Human brain structure changes throughout the lifespan. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental and neurodegenerative diseases. In this study, we identified common genetic variants that affect rates of brain … Continue reading

Posted in Uncategorized | Comments Off on Genetic variants associated with longitudinal changes in brain structure across the lifespan

Abstract: “Exposure to ambient air pollution is a well-established determinant of health and disease. The Lancet Commission on pollution and health concludes that air pollution is the leading environmental cause of global disease and premature death. Indeed, there is a … Continue reading

Posted in Uncategorized | Comments Off on Ambient Air Pollution Increases the Risk of Cerebrovascular and Neuropsychiatric Disorders through Induction of Inflammation and Oxidative Stress

Abstract: “Lung infections and smoking are risk factors for multiple sclerosis, a T-cell-mediated autoimmune disease of the central nervous system. In addition, the lung serves as a niche for the disease-inducing T cells for long-term survival and for maturation into migration-competent … Continue reading

Posted in Uncategorized | Comments Off on The lung microbiome regulates brain autoimmunity

Abstract: SARS-CoV-2 can cause acute respiratory distress and death in some patients. Although severe COVID-19 disease is linked to exuberant inflammation, how SARS-CoV-2 triggers inflammation is not understood. Monocytes and macrophages are sentinel cells that sense invasive infection to form inflammasomes … Continue reading

Posted in Uncategorized | Comments Off on SARS-CoV-2 infection of monocytes activates inflammation

Abstract:  The acute cerebral ischemia induced by the COVID-19 vaccine is one of the side effects. We report the first case of a patient who suffered from a neurological deficit mimicking a stroke after receiving his 1st dose of the … Continue reading

Posted in Uncategorized | Comments Off on Acute ischemic stroke after first dose of inactivated COVID-19 vaccine: A case report

Abstract: Background: Systemic reactivation of Epstein-Barr virus (EBV) may occur in novel coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). However, the clinical consequences of EBV reactivation remain uncertain. Methods: In this retrospective study, we … Continue reading

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https://www.science.org/doi/10.1126/scitranslmed.abl7634

Posted in Uncategorized | Comments Off on The niacin receptor HCAR2 modulates microglial response and limits disease progression in a mouse model of Alzheimer’s disease