Author Archives: admin

“Flavonoids are a class of plant-derived dietary polyphenols that have attracted attention for their pro-cognitive and anti-inflammatory effects. The diversity of flavonoids and their extensive in vivo metabolism suggest that a variety of cellular targets in the brain are likely to … Continue reading

Posted in Uncategorized | Comments Off on Mechanisms of dietary flavonoid action in neuronal function and neuroinflammation

The purpose of this study was to examine whether the APOE ε4 allele modifies the cognitive benefits of a multidomain lifestyle intervention. Participants (ages 60-77 years) were randomly assigned to a multidomain intervention group (diet, exercise, cognitive training, and vascular … Continue reading

Posted in Uncategorized | Comments Off on Alzheimer disease: APOE ε4 affects cognitive decline but does not block benefits of healthy lifestyle

“During evolution, individuals whose brains and bodies functioned well in a fasted state were successful in acquiring food, enabling their survival and reproduction. With fasting and extended exercise, liver glycogen stores are depleted and ketones are produced from adipose-cell-derived fatty … Continue reading

Posted in Uncategorized | Comments Off on Intermittent metabolic switching, neuroplasticity and brain health

A diet rich in salt is linked to an increased risk of cerebrovascular diseases and dementia, but it remains unclear how dietary salt harms the brain. Faraco and colleagues report that, in mice, excess dietary salt suppresses resting cerebral blood … Continue reading

Posted in Uncategorized | Comments Off on Dietary salt promotes neurovascular and cognitive dysfunction

“Superconducting computing chips modelled after neurons can process information faster and more efficiently than the human brain. That achievement, described in Science Advances below, is a key benchmark in the development of advanced computing devices designed to mimic biological systems. And … Continue reading

Posted in Uncategorized | Comments Off on Artificial neurons compute faster than the human brain

http://www.sciencemag.org/collections/bridging-divide-interdisciplinary-research-vulnerable-populations-china Bridging the divide: Interdisciplinary research into vulnerable populations in China 29 DECEMBER 2017

Posted in Uncategorized | Comments Off on Bridging the divide: Interdisciplinary research into vulnerable populations in China

“During evolution, individuals whose brains and bodies functioned well in a fasted state were successful in acquiring food, enabling their survival and reproduction. With fasting and extended exercise, liver glycogen stores are depleted and ketones are produced from adipose-cell-derived fatty … Continue reading

Posted in Uncategorized | Comments Off on Intermittent metabolic switching, neuroplasticity and brain health

Learning reflects the influence of experience on genetically determined circuitry, but little is known about how experience and genetics interact to determine learned phenotypes. Here, Mets and Brainard use vocal learning in songbirds to study genetic influences on learned behavior. … Continue reading

Posted in Uncategorized | Comments Off on Genetic variation interacts with experience to determine interindividual differences in learning

ABSTRACT SUMMARY AND GOALS: To update the 2001 American Academy of Neurology (AAN) guideline on mild cognitive impairment (MCI). METHODS and RESULTS: The guideline panel systematically reviewed MCI prevalence, prognosis, and treatment articles according to AAN evidence classification criteria, and … Continue reading

Posted in Uncategorized | Comments Off on Mild cognitive impairment: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology

The BDNF mimetic compound 7,8-dihydroxyflavone (7,8-DHF), a potent small molecular TrkB agonist, displays prominent therapeutic efficacy against Alzheimer’s disease. However, 7,8-DHF has only modest oral bioavailability and a moderate pharmacokinetic profile. To alleviate these preclinical obstacles, the authors used a … Continue reading

Posted in Uncategorized | Comments Off on BDNF mimetic prodrug for treating Alzheimer’s disease