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Abstract: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system that involves demyelination and axonal degeneration. Although substantial progress has been made in drug development for relapsing-remitting MS, treatment of the progressive forms of the disease, … Continue reading

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Abbreviated Abstract:  Adverse childhood experiences such as early life adversity or stress and childhood trauma have a lifelong impact on mental and physical health. Childhood trauma has been associated with posttraumatic stress disorder (PTSD), anxiety, depression, bipolar disorder, diabetes, and cardiovascular disease. However, … Continue reading

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Abstract: “Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost … Continue reading

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In the current longitudinal study, Saarikivi and colleagues investigated the development of working memory in musically trained and nontrained children and adolescents, aged 9–20. Working memory was measured with the Digit Span (DS) forwards and backwards tests (N = 106) and … Continue reading

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Abstract: “Inflammatory processes are known to contribute to tissue damage in the central nervous system (CNS) across a broad range of neurological conditions, including stroke. Gamma amino butyric acid (GABA), the main inhibitory neurotransmitter in the CNS, has been implicated … Continue reading

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Journal Club: “The presentation and development of psychiatric illnesses is affected by interindividual variability in brain morphology and genetics. Epigenetic factors and early life experiences can also alter brain development and influence psychiatric illness susceptibility. For example, interactions between genetic … Continue reading

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The present study provides evidence for a prodromal phase of multiple sclerosis, with implications for studying disease aetiology and underscoring the limitations of therapies that solely target inflammation. The findings also suggest an opportunity to apply secondary prevention strategies at … Continue reading

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Migraine can be regarded as a conserved, adaptive response that occurs in genetically predisposed individuals with a mismatch between the brain’s energy reserve and workload. Given the high prevalence of migraine, genotypes associated with the condition seem likely to have … Continue reading

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To analyze music preferences in human subjects, Gold and colleagues built a computer model to analyze songs quantitatively. The researchers fed the model a large musical repertoire, including Canadian and German folk songs and Bach compositions. This training allowed the … Continue reading

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Previous studies identified several separate risk factors for stress-induced disorders. The authors of the present study tested whether they could use an integrated approach to predict susceptibility or resilience to social defeat stress (SDS) in mice and whether administration of … Continue reading

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