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Reliable execution of precise behaviors requires that brain circuits are resilient to variations in neuronal dynamics. Genetic perturbation of the majority of excitatory neurons in HVC, a brain region involved in song production, in adult songbirds with stereotypical songs triggered … Continue reading

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https://www.nature.com/articles/d41586-024-01387-9 Researchers have mapped a tiny piece of the human brain in astonishing detail. The resulting cell atlas, which was described in Science and is available online, reveals new patterns of connections between brain neurons, as well as cells that wrap … Continue reading

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Multiple sclerosis (MS) is a global health concern affecting around 2.6 million people. It is characterised by neural inflammation, myelin breakdown and cognitive decline. Cognitive impairment, especially reduced cognitive processing speed (CPS), which affects up to 67% of MS patients … Continue reading

Posted in Uncategorized | Comments Off on The Impact of Exercise on Multiple Sclerosis and Cognitive Health

SCH23390 is a widely used D1 dopamine receptor (D1R) antagonist that also elicits some D1R-independent effects. We previously found that the benzazepine, SKF83959, an analog of SCH23390, produces positive allosteric modulation of the Sigma-1 receptor (Sig1R). SCH23390 does not bind … Continue reading

Posted in Uncategorized | Comments Off on The classical D1 dopamine receptor antagonist SCH23390 is a functional sigma-1 receptor allosteric modulator

Abstract: Although B cells are implicated in multiple sclerosis (MS) pathophysiology, a predictive or diagnostic autoantibody remains elusive. In this study, the Department of Defense Serum Repository (DoDSR), a cohort of over 10 million individuals, was used to generate whole-proteome autoantibody … Continue reading

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Abstract: Parkinson’s disease and inflammatory bowel disease have been increasingly associated, implying shared pathophysiology. To explore biological explanations for the reported connection, we leveraged summary statistics of updated genome-wide association studies and characterized the genetic overlap between the two diseases. Aggregated … Continue reading

Posted in Uncategorized | Comments Off on Genetic overlap between Parkinson’s disease and inflammatory bowel disease

Editor’s summary: The autoimmune disease multiple sclerosis (MS) is a highly heterogeneous disease with many different treatment options. However, it is not clear whether certain features of MS are associated with distinct immune signatures or would benefit from particular therapies. Here, … Continue reading

Posted in Uncategorized | Comments Off on Multiple sclerosis endophenotypes identified by high-dimensional blood signatures are associated with distinct disease trajectories

Abstract:   Aims: According to Braak’s hypothesis, it is plausible that Parkinson’s disease (PD) originates in the enteric nervous system (ENS) and spreads to the brain through the vagus nerve. In this work, we studied whether inflammatory bowel diseases (IBDs) … Continue reading

Posted in Uncategorized | Comments Off on Inflammatory bowel disease induces pathological α-synuclein aggregation in the human gut and brain

Abstract: The expanding field of precision gene editing using CRISPR/Cas9 has demonstrated its potential as a transformative technology in the treatment of various diseases. However, whether this genome-editing tool could be used to modify neural circuits in the central nervous … Continue reading

Posted in Uncategorized | Comments Off on Genetic modulation of the HTR2A gene reduces anxiety-related behavior

Abstract: “Ageing of the immune system is characterized by decreased lymphopoiesis and adaptive immunity, and increased inflammation and myeloid pathologies. Age-related changes in populations of self-renewing haematopoietic stem cells (HSCs) are thought to underlie these phenomena. During youth, HSCs with balanced output … Continue reading

Posted in Uncategorized | Comments Off on Anti-ageing antibodies revive the immune system