Author Archives: admin

Abstract Importance: Coronavirus disease 2019 (COVID-19) may lead to serious illness as a result of an excessive immune response. Fluvoxamine may prevent clinical deterioration by stimulating the σ-1 receptor, which regulates cytokine production. Objective: To determine whether fluvoxamine, given during … Continue reading

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Summary: “An aspirin to make CSCs go away: Cancer stem cells (CSCs) are tumor cells with stem cell-like qualities that promote tumor progression, adaption to stress, and resistance to chemotherapy. Bhattacharya et al. found that aspirin targets CSCs in a … Continue reading

Posted in Uncategorized | Comments Off on Aspirin enhances efficacy of chemotherapy via suppression of drug efflux pump ABCG2

https://www.nature.com/articles/d41586-020-02957-3

Posted in Uncategorized | Comments Off on Neanderthal DNA highlights complexity of COVID risk factors

Abstract: “The mechanisms by which prenatal immune activation increase the risk for neuropsychiatric disorders are unclear. Here, we generated developmental cortical interneurons (cINs)-which are known to be affected in schizophrenia (SCZ) when matured-from induced pluripotent stem cells (iPSCs) derived from … Continue reading

Posted in Uncategorized | Comments Off on Activated microglia cause metabolic disruptions in developmental cortical interneurons that persist in interneurons from individuals with schizophrenia

 Abstract:  “In less than 6 months, the severe acute respiratory syndrome-coronavirus type 2 (SARS-CoV-2) has spread worldwide infecting nearly 6 million people and killing over 350,000. Initially thought to be restricted to the respiratory system, we now understand that coronavirus … Continue reading

Posted in Uncategorized | Comments Off on COVID-19: A Global Threat to the Nervous System

Summary: ”The neuropeptide oxytocin is an important regulator of social behavior and is widely considered to reduce anxiety-related behaviors. However, growing evidence suggests that sometimes oxytocin increases anxiety. How can the same molecule have such different effects on behavior? Here … Continue reading

Posted in Uncategorized | Comments Off on Extrahypothalamic oxytocin neurons drive stress-induced social vigilance and avoidance

Liotta EM et al: Frequent neurologic manifestations and encephalopathy‐associated morbidity in Covid‐19 patients. Annals of Clinical and Translational Neurology [Epub ahead of print, Oct. 5, 2020;https://doi.org/10.1002/acn3.51210 ] https://onlinelibrary.wiley.com/doi/full/10.1002/acn3.51210

Posted in Uncategorized | Comments Off on Frequent neurologic manifestations and encephalopathy‐associated morbidity in Covid‐19 patients

https://media.nature.com/original/magazine-assets/d41586-020-02713-7/d41586-020-02713-7.pdf  

Posted in Uncategorized | Comments Off on Brain’s immune cells put the brakes on neurons

Abstract: “Parkinson’s disease (PD) pathogenesis may involve the epigenetic control of enhancers that modify neuronal functions. Here, we comprehensively examine DNA methylation at enhancers, genome-wide, in neurons of patients with PD and of control individuals. We find a widespread increase … Continue reading

Posted in Uncategorized | Comments Off on Epigenomic analysis of Parkinson’s disease neurons identifies Tet2 loss as neuroprotective

Abstract: “‘Dysbiosis’ of the maternal gut microbiome, in response to challenges such as infection1, altered diet2 and stress3 during pregnancy, has been increasingly associated with abnormalities in brain function and behaviour of the offspring4. However, it is unclear whether the maternal … Continue reading

Posted in Uncategorized | Comments Off on The maternal microbiome modulates fetal neurodevelopment in mice