Author Archives: admin

The purpose of this study was to estimate the percentage contribution of genetic and environmental factors to Autism Spectrum Disorder (ASD). Children from Denmark, Finland, Sweden, Israel, and Western Australia who were born between January 1, 1998, and December 31, … Continue reading

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Abstract: “Mitochondria vary in morphology and function in different tissues; however, little is known about their molecular diversity among cell types. Here we engineered MitoTag mice, which express a Cre recombinase-dependent green fluorescent protein targeted to the outer mitochondrial membrane, and … Continue reading

Posted in Uncategorized | Comments Off on Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity

Chronic pain is associated with anxio-depressive comorbidities, but the neuroanatomical substrates remain unknown. A specific serotonergic pathway from the dorsal raphe nucleus to the lateral habenula via the central amygdala is now uncovered as a key neural circuit governing comorbid … Continue reading

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Patients with brain tumours have a range of symptoms that can vary in severity, from headaches to a decline in cognitive function. The symptoms depend on the tumour type and its size, location and growth rate. Understanding what controls the … Continue reading

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Abbreviated Abstract: Adverse childhood experiences are associated with mental and physical health risks that, through biological and psychosocial pathways, likely span generations. Within an individual, telomere length, an established marker of cellular stress and aging, is associated with both adverse childhood experiences and psychopathology, providing the … Continue reading

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Insulin resistance in humans is associated with increased risk of major depression. Such a relationship has been also found in rodents fed a high-fat diet. To determine whether insulin-sensitizing strategies induce anxiolytic- and/or antidepressant-like activities and to investigate the underlying … Continue reading

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Abstract: “Psychiatric morbidity is high in cities, so identifying potential modifiable urban protective factors is important. We show that exposure to urban green space improves well-being in naturally behaving male and female city dwellers, particularly in districts with higher psychiatric … Continue reading

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Abstract: “β-amyloid (Aβ)-dependent neuronal hyperactivity is believed to contribute to the circuit dysfunction that characterizes the early stages of Alzheimer’s disease (AD). Although experimental evidence in support of this hypothesis continues to accrue, the underlying pathological mechanisms are not well understood. In this experiment, we used … Continue reading

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Abbreviated Abstract: “Aging drives a progressive decline in cognition and decreases synapse numbers and synaptic function in the brain, thereby increasing the risk for neurodegenerative disease. Pioneering studies showed that introduction of blood from young mice into aged mice reversed age-associated cognitive impairments … Continue reading

Posted in Uncategorized | Comments Off on Specific factors in blood from young but not old mice directly promote synapse formation and NMDA-receptor recruitment

Abstract: “Science fiction notions of altering problematic memories are starting to become reality as techniques emerge through which unique memories can be edited. Here we review memory-editing research with a focus on improving the treatment of psychopathology. Studies highlight two … Continue reading

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