Monthly Archives: December 2014

Gene expression and regulation are important modifiers of behavior. Epigenetic mechanisms regulate gene expression via chemical protein modifications or through methylation of genes themselves. In this review, Dias and colleagues outline epigenetic mechanisms by which gene expression is regulated in … Continue reading →

“Sensory processing deficits, first investigated by Kraepelin and Bleuler as possible pathophysiological mechanisms in schizophrenia, are now being recharacterized in the context of our current understanding of the molecular and neurobiological brain mechanisms involved. The National Institute of Mental Health … Continue reading →

Most species, including humans and fruit flies, exhibit age-related memory impairment. Various causes have been proposed, many of which converge on a mechanism involving cumulative oxidative damage. This hypothesis remains controversial, however. Yamazaki and colleagues now show that in Drosophila … Continue reading →

The purpose of this study was to identify biological pathways that contribute to risk for bipolar disorder using genes with consistent evidence for association in multiple genome-wide association studies (GWAS). The authors identified 966 genes that contained 2 or more … Continue reading →

Major depressive disorder has been linked with inflammatory processes, but it is unclear whether individual differences in levels of inflammatory biomarkers could help match patients to treatments that are most likely to be beneficial. The authors tested the hypothesis that … Continue reading →