Monthly Archives: July 2012

Mitochondrial dysfunction has been linked to neurodegenerative disorders such as Parkinson disease. However it is likely that there are also other important players in neurodegenerative processes and that these players may differ in different neurodegenerative diseases. In this study the … Continue reading →

Chronic sleep deprivation disrupts the circadian clock and increases susceptibility to diseases such as diabetes, obesity, and cancer. Increased inflammation is one of the common underlying mechanisms of these diseases in addition to being a factor in mood disorders such … Continue reading →

Parkin and PINK1 protein mutants are implicated in familial Parkinson disease and promote fragmentation and turnover of mitochondria after mitochondrial depolarization. In this paper, the authors show that the PINK1/Parkin pathway selectively influences the integrity of mitochondria in dopaminergic neurons. … Continue reading →

Multiple sclerosis is considered to be an autoimmune, inflammatory disease of the CNS. In most patients, the disease follows a relapsing–remitting course and is characterized by dynamic inflammatory demyelinating lesions in the CNS. Although on the surface multiple sclerosis may … Continue reading →