Monthly Archives: January 2020

Early-Life Environmental Factors Impacting the Development of Psychopathology Posted on January 29, 2020 by admin

Early-Life Environmental Factors Impacting the Development of Psychopathology Published Online:1 Jan 2020https://doi.org/10.1176/appi.ajp.2019.1911118 https://ajp.psychiatryonline.org/doi/pdf/10.1176/appi.ajp.2019.19111181

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Somatostatin interneurons in the prefrontal cortex control affective state discrimination in mice Posted on January 28, 2020 by admin

Abstract: “The prefrontal cortex (PFC) is implicated in processing of the affective state of others through non-verbal communication. This social cognitive function is thought to rely on an intact cortical neuronal excitatory and inhibitory balance. Here combining in vivo electrophysiology … Continue reading →

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Evaluation of anti-inflammatory agents for Alzheimer’s disease Posted on January 20, 2020 by admin

Summary: “Evidence suggests that chronic neuroinflammation has an important role in the pathogenesis of Alzheimer disease. However, in a new clinical trial, the tetracycline antibiotic minocycline, which has anti-inflammatory properties, failed to delay disease progression in individuals with mild Alzheimer … Continue reading →

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Dendritic action potentials and computation in human layer 2/3 cortical neurons Posted on January 10, 2020 by admin

“Human dendrites are special A special developmental program in the human brain drives the disproportionate thickening of cortical layer 2/3. This suggests that the expansion of layer 2/3, along with its numerous neurons and their large dendrites, may contribute to … Continue reading →

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The cytokine IL-17A as a marker of treatment resistance in major depressive disorder? Posted on January 8, 2020 by admin

Abstract: “Major depression is a complex disease and-among others, inflammation appears to play an important role in its pathophysiology. In this study, we investigated a broad range of cytokines in depressed patients. Plasma levels of interleukin (IL)-12/ IL-23p40, IL-15, IL-16, … Continue reading →

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Inflammation, insulin resistance and neuroprogression in depression Posted on January 4, 2020 by admin

Abstract: “Chronic low-grade inflammation has been observed in major depression and other major psychiatric disorders and has been implicated in metabolic changes that are commonly associated with these disorders. This raises the possibility that the effects of dysfunctional metabolism may … Continue reading →

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Resilience and the brain: a key role for regulatory circuits linked to social stress and support Posted on January 1, 2020 by admin

Abstract: “Given the high prevalence and burden of mental disorders, fostering the understanding of protective factors is an urgent issue for translational medicine in psychiatry. The concept of resilience describes individual and environmental protective factors against the backdrop of established … Continue reading →

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