Monthly Archives: January 2020

Summary: “Evidence suggests that chronic neuroinflammation has an important role in the pathogenesis of Alzheimer disease. However, in a new clinical trial, the tetracycline antibiotic minocycline, which has anti-inflammatory properties, failed to delay disease progression in individuals with mild Alzheimer … Continue reading

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“Human dendrites are special A special developmental program in the human brain drives the disproportionate thickening of cortical layer 2/3. This suggests that the expansion of layer 2/3, along with its numerous neurons and their large dendrites, may contribute to … Continue reading

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Abstract: “Major depression is a complex disease and-among others, inflammation appears to play an important role in its pathophysiology. In this study, we investigated a broad range of cytokines in depressed patients. Plasma levels of interleukin (IL)-12/ IL-23p40, IL-15, IL-16, … Continue reading

Posted in Uncategorized | Comments Off on The cytokine IL-17A as a marker of treatment resistance in major depressive disorder?

Abstract: “Chronic low-grade inflammation has been observed in major depression and other major psychiatric disorders and has been implicated in metabolic changes that are commonly associated with these disorders. This raises the possibility that the effects of dysfunctional metabolism may … Continue reading

Posted in Uncategorized | Comments Off on Inflammation, insulin resistance and neuroprogression in depression

Abstract: “Given the high prevalence and burden of mental disorders, fostering the understanding of protective factors is an urgent issue for translational medicine in psychiatry. The concept of resilience describes individual and environmental protective factors against the backdrop of established … Continue reading

Posted in Uncategorized | Comments Off on Resilience and the brain: a key role for regulatory circuits linked to social stress and support