Monthly Archives: March 2018

“Excessive dopamine neurotransmission underlies psychotic episodes as observed in patients with some types of bipolar disorder and schizophrenia. The dopaminergic hypothesis was postulated after the finding that antipsychotics were effective to halt increased dopamine tone. However, there is little evidence for dysfunction within … Continue reading

Posted in Uncategorized | Comments Off on Deletion of dopamine D2 receptors from parvalbumin interneurons causes schizophrenia-like phenotypes

The purpose of this study was to investigate whether greater cardiovascular fitness in midlife is associated with decreased dementia risk in women followed for 44 years. A population-based sample of 1,462 women 38 to 60 years of age was examined … Continue reading

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Patients surviving a stroke are at increased risk for subsequent cardiovascular events and accelerated atherosclerosis. Roth and colleagues now show that stroke exacerbates atherosclerosis progression via alarmin-mediated propagation of vascular inflammation. Recruitment of activated monocytes via the CC-chemokine ligand 2–CC-chemokine … Continue reading

Posted in Uncategorized | Comments Off on Brain-released alarmins and stress response synergize in accelerating atherosclerosis progression after stroke

“New neurons continue to be generated in the subgranular zone of the dentate gyrus of the adult mammalian hippocampus. This process has been linked to learning and memory, stress and exercise, and is thought to be altered in neurological disease. In humans, … Continue reading

Posted in Uncategorized | Comments Off on Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults

This study examined the risks of myocardial infarction, stroke, peripheral artery disease, venous thromboembolism, atrial fibrillation, and heart failure in patients with migraine and in a general population comparison cohort. Higher risks were observed among patients with incident migraine than in the general population across most … Continue reading

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The blood-brain barrier (BBB) is a continuous endothelial membrane within brain microvessels that has sealed cell-to-cell contacts and is sheathed by mural vascular cells and perivascular astrocyte end-feet. The BBB protects neurons from factors present in the systemic circulation and … Continue reading

Posted in Uncategorized | Comments Off on Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders