Monthly Archives: March 2017

Although understanding of the biological mechanisms of stroke have advanced considerably in animal models, this progress has not been translated into improvements to restorative therapies following stroke in humans. In this review, Ward discusses the reasons behind this lack of … Continue reading

Posted in Uncategorized | Comments Off on Restoring brain function after stroke – bridging the gap between animals and humans

The CA3 region of the hippocampus is important for rapid encoding of memory. Computational theories have proposed specific roles in hippocampal function and memory for the sparse inputs from the dentate gyrus to CA3 and for the extended local recurrent … Continue reading

Posted in Uncategorized | Comments Off on Operation and plasticity of hippocampal CA3 circuits: implications for memory encoding

“Incident stroke has long been recognized to cause dementia shortly after the event. Patients who survive stroke without early-onset poststroke dementia (PSD) are at a high risk of developing dementia months to years after the initial stroke incident, which has generated enthusiasm for exploring treatments to prevent delayed-onset PSD … Continue reading

Posted in Uncategorized | Comments Off on Early-onset and delayed-onset poststroke dementia – revisiting the mechanisms

“Research in humans and nonhuman animals indicates that social affiliation, and particularly maternal bonding, depends on reward circuitry. Although numerous mechanistic studies in rodents demonstrated that maternal bonding depends on striatal dopamine transmission, the neurochemistry supporting maternal behavior in humans has not been described so … Continue reading

Posted in Uncategorized | Comments Off on Dopamine in the medial amygdala network mediates human bonding