Category Archives: Uncategorized

Abstract:  “Parkinson’s disease is a neurodegenerative disorder with motor symptoms linked to the loss of dopaminergic neurons in the substantia nigra compacta. Although the mechanisms that trigger the loss of dopaminergic neurons are unclear, mitochondrial dysfunction and inflammation are thought … Continue reading

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Summary: Migraine is a prevalent disorder, affecting 15.1% of the world’s population. In most cases, the migraine attacks are sporadic; however, some individuals experience a gradual increase in attack frequency over time, and up to 2% of the general population develops chronic migraine. The … Continue reading

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Abbreviated Abstract: “Public health is a priority for the Chinese Government. Evidence-based decision making for health at the province level in China, which is home to a fifth of the global population, is of paramount importance. This analysis uses data … Continue reading

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Some people experience auditory sensations when seeing visual flashes or movements. This prevalent synaesthesia-like visually evoked auditory response could result either from overexuberant cross-activation between brain areas and/or reduced inhibition of normally occurring cross-activation. The authors of this paper have … Continue reading

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Abstract:  “Sleep is essential to all animals with a nervous system. Nevertheless, the core cellular function of sleep is unknown, and there is no conserved molecular marker to define sleep across phylogeny. Time-lapse imaging of chromosomal markers in single cells of live zebrafish revealed that sleep increases … Continue reading

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Abstract: “Cerebral blood flow is reduced early in Alzheimer’s disease (AD). Because most of the vascular resistance within the brain is in capillaries, this could reflect dysfunction of contractile pericytes on capillary walls. Here we used live and rapidly-fixed biopsied … Continue reading

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Abstract: “The past decade has seen a dramatic expansion of the field of prodromal Parkinson’s disease (PD). Ten years ago, there were only six known prodromal markers of disease, none of which had more than two studies documenting diagnostic value. … Continue reading

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Summary: “Some of the most effective new pharmaceutical drugs are highly complex biological molecules. To make such therapies less expensive and more broadly available, drug developers seek to fashion biosimilars — good-enough copies that can be produced at large scale.”  … Continue reading

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Abstract: “Multiple sclerosis (MS) is characterized by inflammatory insults that drive neuroaxonal injury. However, knowledge about neuron-intrinsic responses to inflammation is limited. By leveraging neuron-specific messenger RNA profiling, we found that neuroinflammation leads to induction and toxic accumulation of the synaptic … Continue reading

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Abstract:  “Mental health and well-being are consistently influenced-directly or indirectly-by multiple environmental exposures. In this review, we have attempted to address some of the most common exposures of the biophysical environment, with a goal of demonstrating how those factors interact … Continue reading

Posted in Uncategorized | Comments Off on Environmental Exposures and Depression: Biological Mechanisms and Epidemiological Evidence