Category Archives: Uncategorized

Abstract: “The mechanisms by which prenatal immune activation increase the risk for neuropsychiatric disorders are unclear. Here, we generated developmental cortical interneurons (cINs)-which are known to be affected in schizophrenia (SCZ) when matured-from induced pluripotent stem cells (iPSCs) derived from … Continue reading

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 Abstract:  “In less than 6 months, the severe acute respiratory syndrome-coronavirus type 2 (SARS-CoV-2) has spread worldwide infecting nearly 6 million people and killing over 350,000. Initially thought to be restricted to the respiratory system, we now understand that coronavirus … Continue reading

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Summary: ”The neuropeptide oxytocin is an important regulator of social behavior and is widely considered to reduce anxiety-related behaviors. However, growing evidence suggests that sometimes oxytocin increases anxiety. How can the same molecule have such different effects on behavior? Here … Continue reading

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Liotta EM et al: Frequent neurologic manifestations and encephalopathy‐associated morbidity in Covid‐19 patients. Annals of Clinical and Translational Neurology [Epub ahead of print, Oct. 5, 2020;https://doi.org/10.1002/acn3.51210 ] https://onlinelibrary.wiley.com/doi/full/10.1002/acn3.51210

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https://media.nature.com/original/magazine-assets/d41586-020-02713-7/d41586-020-02713-7.pdf  

Posted in Uncategorized | Comments Off on Brain’s immune cells put the brakes on neurons

Abstract: “Parkinson’s disease (PD) pathogenesis may involve the epigenetic control of enhancers that modify neuronal functions. Here, we comprehensively examine DNA methylation at enhancers, genome-wide, in neurons of patients with PD and of control individuals. We find a widespread increase … Continue reading

Posted in Uncategorized | Comments Off on Epigenomic analysis of Parkinson’s disease neurons identifies Tet2 loss as neuroprotective

Abstract: “‘Dysbiosis’ of the maternal gut microbiome, in response to challenges such as infection1, altered diet2 and stress3 during pregnancy, has been increasingly associated with abnormalities in brain function and behaviour of the offspring4. However, it is unclear whether the maternal … Continue reading

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“Our results show that the experience of being alone has immediate consequences on brain gene activity. Clearly this is important for the human context, where loneliness (i.e., perceived social isolation) is a risk factor for psychological and neurodegenerative disorders. As … Continue reading

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“Parkinson’s disease or parkinsonism have been described after infections by viruses, such as influenza A, Epstein-Barr virus, varicella zoster, hepatitis C virus, HIV, Japanese encephalitis virus, or West Nile virus. We report a patient with probable Parkinson’s disease, who was diagnosed … Continue reading

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ESSAYS ON SCIENCE AND SOCIETY NEUROMODULATION Hong G: Seeing the sound. Science 369(6504): 638 (2020). https://science.sciencemag.org/content/sci/369/6504/638.full.pdf

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