Category Archives: Uncategorized

Abstract: “Inflammatory processes are known to contribute to tissue damage in the central nervous system (CNS) across a broad range of neurological conditions, including stroke. Gamma amino butyric acid (GABA), the main inhibitory neurotransmitter in the CNS, has been implicated … Continue reading

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Journal Club: “The presentation and development of psychiatric illnesses is affected by interindividual variability in brain morphology and genetics. Epigenetic factors and early life experiences can also alter brain development and influence psychiatric illness susceptibility. For example, interactions between genetic … Continue reading

Posted in Uncategorized | Comments Off on DNA Methylation within the Amygdala Early in Life Increases Susceptibility for Depression and Anxiety Disorders

The present study provides evidence for a prodromal phase of multiple sclerosis, with implications for studying disease aetiology and underscoring the limitations of therapies that solely target inflammation. The findings also suggest an opportunity to apply secondary prevention strategies at … Continue reading

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Migraine can be regarded as a conserved, adaptive response that occurs in genetically predisposed individuals with a mismatch between the brain’s energy reserve and workload. Given the high prevalence of migraine, genotypes associated with the condition seem likely to have … Continue reading

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To analyze music preferences in human subjects, Gold and colleagues built a computer model to analyze songs quantitatively. The researchers fed the model a large musical repertoire, including Canadian and German folk songs and Bach compositions. This training allowed the … Continue reading

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Previous studies identified several separate risk factors for stress-induced disorders. The authors of the present study tested whether they could use an integrated approach to predict susceptibility or resilience to social defeat stress (SDS) in mice and whether administration of … Continue reading

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The purpose of this study was to estimate the percentage contribution of genetic and environmental factors to Autism Spectrum Disorder (ASD). Children from Denmark, Finland, Sweden, Israel, and Western Australia who were born between January 1, 1998, and December 31, … Continue reading

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Abstract: “Mitochondria vary in morphology and function in different tissues; however, little is known about their molecular diversity among cell types. Here we engineered MitoTag mice, which express a Cre recombinase-dependent green fluorescent protein targeted to the outer mitochondrial membrane, and … Continue reading

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Chronic pain is associated with anxio-depressive comorbidities, but the neuroanatomical substrates remain unknown. A specific serotonergic pathway from the dorsal raphe nucleus to the lateral habenula via the central amygdala is now uncovered as a key neural circuit governing comorbid … Continue reading

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Patients with brain tumours have a range of symptoms that can vary in severity, from headaches to a decline in cognitive function. The symptoms depend on the tumour type and its size, location and growth rate. Understanding what controls the … Continue reading

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