Category Archives: Uncategorized

Major depressive disorder is associated with an increased risk of mortality and aging-related diseases. In this study, the authors examined whether major depression is associated with higher epigenetic aging in blood as measured by DNA methylation patterns, and whether clinical … Continue reading

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“Transgenerational epigenetic inheritance refers to the transmission of epigenetic information through the germline. While it has been observed in plants, nematodes and fruit flies, its occurrence in mammals-and humans in particular-is the matter of controversial debate, mostly because the study … Continue reading

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“Despite its long history, until now, no receptor has been identified for aspirin, one of the most widely used medicines worldwide.” Here Patel and colleagues report that peroxisome proliferator-activated receptor alpha (PPARα), a nuclear hormone receptor involved in fatty acid … Continue reading

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“Recent research has identified human subjects who have highly superior autobiographical memory (HSAM). Here, (Santangelo and colleagues) investigated, using fMRI, the neural activation induced by retrieval of autobiographical memories (AMs) and semantic memories (SMs) in subjects with HSAM and control … Continue reading

Posted in Uncategorized | Comments Off on Enhanced brain activity associated with memory access in highly superior autobiographical memory

Abstract: “Detection of incipient Alzheimer disease (AD) pathophysiology is critical to identify preclinical individuals and target potentially disease-modifying therapies towards them. Current neuroimaging and biomarker research is strongly focused in this direction, with the aim of establishing AD fingerprints to … Continue reading

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Hippocampus-dependent, event-related memories formed in early infancy in human and non-human animals are rapidly forgotten. Recently the authors reported that high levels of hippocampal neurogenesis contribute to accelerated rates of forgetting during infancy. Here, they ask whether these memories formed … Continue reading

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Abstract: “The most characteristic feature of domestic animals is their change in behavior associated with selection for tameness. Here we show, using high-resolution brain magnetic resonance imaging in wild and domestic rabbits, that domestication reduced amygdala volume and enlarged medial … Continue reading

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“While accounting for only 2% of the body’s weight, the brain utilizes up to 20% of the body’s total energy. Not surprisingly, metabolic dysfunction and energy supply-and-demand mismatch have been implicated in a variety of neurological and psychiatric disorders. Mitochondria … Continue reading

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Activation of microglia by classical inflammatory mediators can convert astrocytes into a neurotoxic A1 phenotype in a variety of neurological diseases. Development of agents that could inhibit the formation of A1 reactive astrocytes could be used to treat disorders for which there are no disease-modifying therapies. Glucagon-like … Continue reading

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Abstract: “Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants … Continue reading

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