Category Archives: Uncategorized

Abbreviated Abstract: Adverse childhood experiences are associated with mental and physical health risks that, through biological and psychosocial pathways, likely span generations. Within an individual, telomere length, an established marker of cellular stress and aging, is associated with both adverse childhood experiences and psychopathology, providing the … Continue reading

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Insulin resistance in humans is associated with increased risk of major depression. Such a relationship has been also found in rodents fed a high-fat diet. To determine whether insulin-sensitizing strategies induce anxiolytic- and/or antidepressant-like activities and to investigate the underlying … Continue reading

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Abstract: “Psychiatric morbidity is high in cities, so identifying potential modifiable urban protective factors is important. We show that exposure to urban green space improves well-being in naturally behaving male and female city dwellers, particularly in districts with higher psychiatric … Continue reading

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Abstract: “β-amyloid (Aβ)-dependent neuronal hyperactivity is believed to contribute to the circuit dysfunction that characterizes the early stages of Alzheimer’s disease (AD). Although experimental evidence in support of this hypothesis continues to accrue, the underlying pathological mechanisms are not well understood. In this experiment, we used … Continue reading

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Abbreviated Abstract: “Aging drives a progressive decline in cognition and decreases synapse numbers and synaptic function in the brain, thereby increasing the risk for neurodegenerative disease. Pioneering studies showed that introduction of blood from young mice into aged mice reversed age-associated cognitive impairments … Continue reading

Posted in Uncategorized | Comments Off on Specific factors in blood from young but not old mice directly promote synapse formation and NMDA-receptor recruitment

Abstract: “Science fiction notions of altering problematic memories are starting to become reality as techniques emerge through which unique memories can be edited. Here we review memory-editing research with a focus on improving the treatment of psychopathology. Studies highlight two … Continue reading

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Chen S: Optical modulation goes deep in the brain. Science 365(6452): 456-457 (2019). https://science.sciencemag.org/content/sci/365/6452/456.full.pdf https://science.sciencemag.org/content/365/6452/456

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“Behavioural evidence suggests that targeting just 20 neurons prompted animals to ‘see’ an image. … Deisseroth’s team showed mice images of either horizontal or vertical bars, and trained the animals to lick from a tube of water whenever they saw … Continue reading

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Abstract:  “Parkinson’s disease is a neurodegenerative disorder with motor symptoms linked to the loss of dopaminergic neurons in the substantia nigra compacta. Although the mechanisms that trigger the loss of dopaminergic neurons are unclear, mitochondrial dysfunction and inflammation are thought … Continue reading

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Summary: Migraine is a prevalent disorder, affecting 15.1% of the world’s population. In most cases, the migraine attacks are sporadic; however, some individuals experience a gradual increase in attack frequency over time, and up to 2% of the general population develops chronic migraine. The … Continue reading

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