Category Archives: Uncategorized

Abstract: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection inhibits mitochondrial oxidative phosphorylation (OXPHOS) and elevates mitochondrial reactive oxygen species (ROS, mROS) which activates hypoxia-inducible factor-1alpha (HIF-1α), shifting metabolism toward glycolysis to drive viral biogenesis but also causing the release of … Continue reading →

Summary: “Osteoarthritis (OA) is a degenerative joint disease and the most common form of arthritis globally, which is a leading cause of disability among the elderly population. The typical symptoms of OA include pain and stiffness in the affected joints. … Continue reading →

Highlights • STING is expressed in human and mouse neurons solely under inflammatory conditions • Excitotoxicity activates a non-canonical STIM1-STING signaling pathway in neurons • Neuronal STING activation leads to autophagic GPX4 degradation and ferroptosis • Targeting neuronal STING protects … Continue reading →

Abstract:    Machine learning can be used to define subtypes of psychiatric conditions based on shared biological foundations of mental disorders. Here we analyzed cross-sectional brain images from 4,222 individuals with schizophrenia and 7038 healthy subjects pooled across 41 international … Continue reading →

OBJECTIVES: Autism spectrum disorder (ASD) is estimated to be ∼10 times higher in children with versus without an autistic sibling in population-based studies. Prospective studies of infant siblings have revealed even higher familial recurrence rates. In the current prospective longitudinal … Continue reading →

Editor’s summary Although gene editing is beginning to achieve clinical acceptance as an intervention for some genetic diseases, difficulties remain. Challenges include efficient editing of cells directly in an organism rather than ex vivo and long-term persistence of the edits, … Continue reading →

Abstract: Chronic low-grade inflammation and neuronal deregulation are two components of a smoldering disease activity that drives the progression of disability in people with multiple sclerosis (MS). Although several therapies exist to dampen the acute inflammation that drives MS relapses, therapeutic … Continue reading →

Abstract: “MiR-142-3p has recently emerged as key factor in tailoring personalized treatments for multiple sclerosis (MS), a chronic autoimmune demyelinating disease of the central nervous system (CNS) with heterogeneous pathophysiology and an unpredictable course. With its involvement in a detrimental … Continue reading →

Abstract:  “Multiple sclerosis (MS) is a condition characterized by inflammation in the central nervous system (CNS), impacting sensory, motor, and cognitive abilities. Globally, around three million individuals are affected by MS, with up to 97,000 cases in Iran attributed to … Continue reading →

Editor’s summary: “Vitamin B12 deficiency can lead to neurological deficits, sometimes in the absence of anemia, and mice and patients with mutations in the transcobalamin receptor CD320 do not develop anemia, suggesting that the mechanisms governing B12 uptake in different … Continue reading →