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Limits to human neurogenesis – really? Lucassen PJ, Toni N, Kempermann G, Frisen J, Gage FH, Swaab DF: Limits to human neurogenesis – really? Molecular Psychiatry [Epub ahead of print, January 7, 2019; doi: 10.1038/s41380-018-0337-5.]. https://www.ncbi.nlm.nih.gov/pubmed/30617274

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Abstract: “Genetic discoveries about human brain development and neuropsychiatric syndromes have changed the landscape of psychiatric research. The genotyping of hundreds of thousands of individuals has identified many hundreds of genomic regions that are associated with psychiatric diagnoses, and progress … Continue reading

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Mitochondrial dysfunction has been implicated in a number of brain disorders. Traditionally, mitochondria and mitochondrial DNA (mtDNA) have been thought to be exclusively maternally inherited in humans. In this report, Luo and colleagues identified three unrelated multigeneration families with a … Continue reading

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Administration of the antidepressant fluoxetine to zebrafish, a common laboratory model, reduced levels of the stress hormone cortisol as well as exploratory behavior, effects that persisted across generations, according to a study by Vera-Chang and colleagues. They state that this … Continue reading

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Cognitive impairment in major depressive disorder (MDD), including remitted major depressive disorder, raises the question whether these cognitive defects are part of preexisting vulnerability or a consequence of the disorder or its treatment. The purpose of this study was to compare (via meta-analysis) … Continue reading

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https://www.nature.com/immersive/d41586-018-07683-5/index.html

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“The ApoE ε4 allele is the most significant genetic risk factor for late-onset Alzheimer disease. The risk conferred by ε4, however, differs across populations, with populations of African ancestry showing lower ε4 risk compared to those of European or Asian ancestry. The … Continue reading

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Revealing the brain’s molecular architecture The PsychENCODE Consortium Science  14 Dec 2018: Vol. 362, Issue 6420, pp. 1262-1263 DOI: 10.1126/science.362.6420.1262 http://science.sciencemag.org/content/362/6420/1262/tab-pdf BRAIN_DEC_2018issue    

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The following report describes how microglia in the brain might have a role in the cognitive impairment (“chemobrain”) seen after chemotherapy cancer treatment. “…Some chemotherapies cause a lasting condition known as ‘chemobrain’, which is marked by deficiencies in attention, information … Continue reading

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Excerpts from article: “The observation that higher rates of schizophrenia and other nonaffective psychotic disorders are associated with city living is robustly replicated across epidemiologic studies conducted throughout Northern Europe and North America. The weight of this evidence, combined with exhaustive … Continue reading

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