Monthly Archives: January 2022

Multiple Early Factors Anticipate Post-Acute COVID-19 Sequelae Posted on January 28, 2022 by admin

Multiple Early Factors Anticipate Post-Acute COVID-19 Sequelae Pre-proof…subject to change before final publication. SUMMARY “Post-acute sequelae of COVID-19 (PASC) represent an emerging global crisis. However, quantifiable risk- factors for PASC and their biological associations are poorly resolved. We executed a … Continue reading →

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Epstein-Barr Virus and Neurological Diseases Posted on January 28, 2022 by admin

Abstract: “Epstein-Barr virus (EBV), also known as human herpesvirus 4, is a double-stranded DNA virus that is ubiquitous in 90-95% of the population as a gamma herpesvirus. It exists in two main states, latent infection and lytic replication, each encoding … Continue reading →

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Epstein-Barr virus and multiple sclerosis Posted on January 28, 2022 by admin

“Infection with the Epstein-Barr virus (EBV) has long been postulated to trigger multiple sclerosis (MS). Prior analyses demonstrated increased serum antibodies to EBV in ∼99.5% of MS patients compared with ∼94% of healthy individuals. ….. Bjornevik et al. analyzed EBV antibodies … Continue reading →

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Mechanisms of action of fluvoxamine for COVID-19: a historical review Posted on January 17, 2022 by admin

Abstract: “The ongoing coronavirus disease 2019 (COVID-19) pandemic caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) accelerates the discovery of prophylactic and therapeutic drugs for persons infected with the virus. Drug repurposing for the COVID-19 pandemic has … Continue reading →

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Insular cortex neurons encode and retrieve specific immune responses Posted on January 13, 2022 by admin

Abstract: “Increasing evidence indicates that the brain regulates peripheral immunity, yet whether and how the brain represents the state of the immune system remains unclear. Here, we show that the brain’s insular cortex (InsCtx) stores immune-related information. Using activity-dependent cell … Continue reading →

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Multiple Sclerosis: inhibition of astrocyte-mediated neuroinflammation and protection against cingulum demyelination via S1P 1 -selective modulation Posted on January 6, 2022 by admin

Abstract:  “Ponesimod is a sphingosine 1-phosphate (S1P) receptor (S1PR) modulator that was recently approved for treating relapsing forms of multiple sclerosis (MS). Three other FDA-approved S1PR modulators for MS-fingolimod, siponimod, and ozanimod-share peripheral immunological effects via common S1P1 interactions, yet … Continue reading →

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SARS-CoV-2 Omicron variant replication in human respiratory tract ex vivo Posted on January 1, 2022 by admin

Abstract: “Emergence of SARS-CoV-2 variants of concern (VOC) with progressively increased transmissibility between humans is a threat to global public health. Omicron variant also evades immunity from natural infection or vaccines1. It is unclear whether its exceptional transmissibility is due … Continue reading →

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