Monthly Archives: April 2023

Pyramidal neurons form active, transient multilayered circuits perturbed by autism-associated mutations Posted on April 29, 2023 by admin

https://www.cell.com/cell/pdf/S0092-8674(23)00299-4.pdf

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Prevalence, Patterns, and Clinical Severity of Long COVID among Chinese Medicine Telemedicine Service Users: Preliminary Results from a Cross-Sectional Study Posted on April 20, 2023 by admin

Introduction: The emergence and persistence of symptoms after acute COVID-19 is expected to become a major burden on healthcare systems. We assessed the features of the post-COVID-19 Syndrome (Long COVID) burden in a cohort of COVID-19 patients during the fifth … Continue reading →

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SARS-CoV-2 Spike Protein Accumulation in the Skull-Meninges- Brain Axis: Potential Implications for Long-Term Neurological Complications in post-COVID-19 Posted on April 18, 2023 by admin

https://www.biorxiv.org/content/10.1101/2023.04.04.535604v1.full.pdf  

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Considerations on gradual glutamate accumulation related to cognitive task performance Posted on April 13, 2023 by admin

Abstract: “Long-lasting activities with high demand in cognitive control are known to result in cognitive fatigue. However, the reason for control cost inflation remains elusive. A neurometabolic account was proposed in a recent study combining magnetic resonance spectroscopy (MRS) with … Continue reading →

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The link between obesity and autoimmunity Posted on April 13, 2023 by admin

“Compelling epidemiological evidence reveals a strong association between being overweight or obese and the risk of developing autoimmune diseases (1). From an immunological standpoint, the cellular and molecular mechanisms linked to this association include the overstimulation of T lymphocytes by … Continue reading →

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Twin study reveals non-heritable immune perturbations in multiple sclerosis Posted on April 13, 2023 by admin

Abstract: “Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system underpinned by partially understood genetic risk factors and environmental triggers and their undefined interactions1,2. Here we investigated the peripheral immune signatures of 61 monozygotic twin pairs … Continue reading →

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Shared molecular signatures between coronavirus infection and neurodegenerative diseases provide targets for broad-spectrum drug development Posted on April 5, 2023 by admin

Abstract: “Growing evidences have suggested the association between coronavirus infection and neurodegenerative diseases. However, the molecular mechanism behind the association is complex and remains to be clarified. This study integrated human genes involved in infections of three coronaviruses including SARS-CoV-2, … Continue reading →

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Neuronal APOE4 removal protects against tau-mediated gliosis, neurodegeneration and myelin deficits Posted on April 1, 2023 by admin

Abstract: Apolipoprotein E4 (APOE4) is the strongest known genetic risk factor for late-onset Alzheimer’s disease (AD). Conditions of stress or injury induce APOE expression within neurons, but the role of neuronal APOE4 in AD pathogenesis is still unclear. Here we report … Continue reading →

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