Monthly Archives: February 2015

Growing evidence suggests that diabetes mellitus is one of the strongest risk factors for developing Alzheimer’s disease. However, it remains unclear why diabetes mellitus accelerates Alzheimer’s pathology. In the present study, the authors performed histopathological and biochemical analyses of brain … Continue reading

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Circuit remodeling driven by pathological forms of synaptic plasticity underlies several psychiatric diseases, including addiction. Deep brain stimulation has been applied to treat a number of neurological and psychiatric conditions, although its effects are transient and mediated by largely unknown … Continue reading

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This review considers the question of whether or not levodopa (l-dopa) is toxic in Parkinson’s disease. L-Dopa is often considered to be the most effective symptomatic treatment for Parkinson’s disease; however, there has been a longstanding concern that l-dopa might … Continue reading

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Disruptions in circadian rhythms and dopaminergic activity are involved in the pathophysiology of bipolar disorder, though their interaction remains unclear. In this report, Sidor and colleagues studied a mouse model that displays spontaneous cycling between mood states. Mice with a … Continue reading

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“Understanding the function of genes mutated in hereditary forms of Parkinson’s disease yields insight into disease etiology and reveals new pathways in cell biology. Although mutations or variants in many genes increase the susceptibility to Parkinson’s disease, only a handful … Continue reading

Posted in Uncategorized | Comments Off on The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease