Monthly Archives: September 2019

Chronic pain is associated with anxio-depressive comorbidities, but the neuroanatomical substrates remain unknown. A specific serotonergic pathway from the dorsal raphe nucleus to the lateral habenula via the central amygdala is now uncovered as a key neural circuit governing comorbid … Continue reading

Posted in Uncategorized | Comments Off on A neural circuit for comorbid depressive symptoms in chronic pain

Patients with brain tumours have a range of symptoms that can vary in severity, from headaches to a decline in cognitive function. The symptoms depend on the tumour type and its size, location and growth rate. Understanding what controls the … Continue reading

Posted in Uncategorized | Comments Off on Synaptic input to glioma cells drives brain tumour progression

Abbreviated Abstract: Adverse childhood experiences are associated with mental and physical health risks that, through biological and psychosocial pathways, likely span generations. Within an individual, telomere length, an established marker of cellular stress and aging, is associated with both adverse childhood experiences and psychopathology, providing the … Continue reading

Posted in Uncategorized | Comments Off on Adverse Childhood Experiences: Implications for Offspring Telomere Length and Psychopathology

Insulin resistance in humans is associated with increased risk of major depression. Such a relationship has been also found in rodents fed a high-fat diet. To determine whether insulin-sensitizing strategies induce anxiolytic- and/or antidepressant-like activities and to investigate the underlying … Continue reading

Posted in Uncategorized | Comments Off on Metformin promotes antidepressant-like effects via reduction in circulating branched-chain amino acids

Abstract: “Psychiatric morbidity is high in cities, so identifying potential modifiable urban protective factors is important. We show that exposure to urban green space improves well-being in naturally behaving male and female city dwellers, particularly in districts with higher psychiatric … Continue reading

Posted in Uncategorized | Comments Off on Brain activity and affective benefit of Urban Green Space Exposure