Monthly Archives: November 2014

“Neurocognitive disorders – including delirium, mild cognitive impairment and dementia – are characterized by decline from a previously attained level of cognitive functioning. These disorders have diverse clinical characteristics and aetiologies, with Alzheimer disease, cerebrovascular disease, Lewy body disease, frontotemporal … Continue reading →

“Conventional behavioural mouse models of depression are often used to study the disorder, but cannot capture the full picture of the human disease.” In this essay, Monteggia and Malenka/Deisseroth present two views about the best research strategies to adopt if … Continue reading →

The dentate gyrus in the hippocampus is considered to be a source of age-related memory decline. Causal evidence is needed, however, to show that dentate gyrus-associated memory decline in otherwise healthy elders can be improved by interventions that enhance dentate … Continue reading →

This study identifies a role for adiponectin in modulating hippocampal neurogenesis and alleviating depression-like behaviors in laboratory animals. Adiponectin is a hormone secreted by adipocytes. The authors report that adiponectin may be an essential factor mediating the antidepressant effects of … Continue reading →

Introduction to Special Issue: Science 346 (6209): 566-567 (2014) . “Should we consider aging a natural part of life or an illness? When it comes to the brain, research has tended to focus on the negative side of aging—Alzheimer’s disease, … Continue reading →