Monthly Archives: November 2022

Fluvoxamine and long COVID-19; a new role for sigma-1 receptor (S1R) agonists Posted on November 29, 2022 by admin

Khani, E., Entezari-Maleki, T. Fluvoxamine and long COVID-19; a new role for sigma-1 receptor (S1R) agonists. Mol Psychiatry (2022). https://doi.org/10.1038/s41380-022-01545-3 https://www.nature.com/articles/s41380-022-01545-3

Posted in Uncategorized | Comments Off on Fluvoxamine and long COVID-19; a new role for sigma-1 receptor (S1R) agonists
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies Posted on November 21, 2022 by admin

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR) doubles with every 5 y of age from childhood onward. Circulating autoantibodies neutralizing IFN-α, IFN-ω, and/or IFN-β are found in ∼20% of deceased patients across age groups, and in … Continue reading →

Posted in Uncategorized | Comments Off on The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 Posted on November 21, 2022 by admin

Zhang Q, Bastard P, Liu Z, Le Pen J, Moncada-Velez M, Chen J, Ogishi M, Sabli IKD, Hodeib S, Korol C, Rosain J, Bilguvar K, Ye J, Bolze A, Bigio B, Yang R, Arias AA, Zhou Q, Zhang Y, Onodi … Continue reading →

Posted in Uncategorized | Comments Off on Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
Interferon resistance of emerging SARS-CoV-2 variants Posted on November 21, 2022 by admin

Guo K, Barrett BS, Morrison JH, Mickens KL, Vladar EK, Hasenkrug KJ, Poeschla EM, Santiago ML. Interferon resistance of emerging SARS-CoV-2 variants. Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2203760119. doi: 10.1073/pnas.2203760119. Epub 2022 Jul 22. PMID: 35867811; … Continue reading →

Posted in Uncategorized | Comments Off on Interferon resistance of emerging SARS-CoV-2 variants
SARS-CoV-2 infects neurons and induces neuroinflammation in a non-human primate model of COVID-19 Posted on November 20, 2022 by admin

https://www.cell.com/cell-reports/pdf/S2211-1247(22)01434-6.pdf

Posted in Uncategorized | Comments Off on SARS-CoV-2 infects neurons and induces neuroinflammation in a non-human primate model of COVID-19
Acute and postacute sequelae associated with SARS-CoV-2 reinfection Posted on November 16, 2022 by admin

Abstract: First infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with increased risk of acute and postacute death and sequelae in various organ systems. Whether reinfection adds to risks incurred after first infection is unclear. Here we … Continue reading →

Posted in Uncategorized | Comments Off on Acute and postacute sequelae associated with SARS-CoV-2 reinfection
Systematic analysis of drug-associated myocarditis reported in the World Health Organization pharmacovigilance database Posted on November 13, 2022 by admin

Nguyen, L.S., Cooper, L.T., Kerneis, M. et al. Systematic analysis of drug-associated myocarditis reported in the World Health Organization pharmacovigilance database. Nat Commun 13, 25 (2022). https://doi.org/10.1038/s41467-021-27631-8 https://www.nature.com/articles/s41467-021-27631-8  

Posted in Uncategorized | Comments Off on Systematic analysis of drug-associated myocarditis reported in the World Health Organization pharmacovigilance database
Myocarditis Higher With Moderna COVID Vaccine, but Overall Risk is Low Posted on November 9, 2022 by admin

Background:  Postmarketing evaluations have linked myocarditis to COVID-19 mRNA vaccines. However few population-based analyses have directly compared the safety of the 2 mRNA COVID-19 vaccines. Objectives: This study aimed to compare the risk of myocarditis, pericarditis, and myopericarditis between BNT162b2 … Continue reading →

Posted in Uncategorized | Comments Off on Myocarditis Higher With Moderna COVID Vaccine, but Overall Risk is Low
Bovine lactoferrin inhibits SARS-CoV-2 and SARS-CoV-1 by targeting the RdRp complex and alleviates viral infection in the hamster model Posted on November 8, 2022 by admin

Abstract: “Breast milk has been found to inhibit coronavirus infection, while the key components and mechanisms are unknown. We aimed to determine the components that contribute to the antiviral effects of breastmilk and explore their potential mechanism. Lactoferrin (Lf) and … Continue reading →

Posted in Uncategorized | Comments Off on Bovine lactoferrin inhibits SARS-CoV-2 and SARS-CoV-1 by targeting the RdRp complex and alleviates viral infection in the hamster model
Molecular mimicry of the receptor-binding domain of the SARS-CoV-2 spike protein: from the interaction of spike-specific antibodies with transferrin and lactoferrin to the antiviral effects of human recombinant lactoferrin Posted on November 6, 2022 by admin

Abstract: The pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection involves dysregulations of iron metabolism, and although the mechanism of this pathology is not yet fully understood, correction of iron metabolism pathways seems a promising pharmacological target. The previously … Continue reading →

Posted in Uncategorized | Comments Off on Molecular mimicry of the receptor-binding domain of the SARS-CoV-2 spike protein: from the interaction of spike-specific antibodies with transferrin and lactoferrin to the antiviral effects of human recombinant lactoferrin