Monthly Archives: June 2015

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In a two-way relationship, the sleep/wake cycle regulates amyloid-β levels and amyloid-β accumulation then disrupts sleep. A quantitative three-way model now suggests that amyloid-β impairs memory via its effect on sleep. Mander and colleagues report that β-amyloid burden in medial … Continue reading

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“Placebo effects are beneficial effects that are attributable to the brain–mind responses to the context in which a treatment is delivered rather than to the specific actions of the drug. They are mediated by diverse processes — including learning, expectations … Continue reading

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Stress is considered a risk factor for mood disorders. The hippocampus is thought to negatively regulate the stress response and to mediate various cognitive and mnemonic aspects of stress-induced impairments, although the neuronal pathways supporting behavioural improvements are largely unknown. … Continue reading

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The purpose of this study was to determine the prevalence and sociodemographic correlates of major depression disorders (MDD) and bipolar disorder (BPD) in a population-based sample in Catalonia (NE Spain). Study subjects were 45 years and older (n=5068). The Patient … Continue reading

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This study tested whether polygenic risk scores for schizophrenia and bipolar disorder would predict creativity. The authors found that higher scores were associated with artistic society membership or creative profession in both Icelandic and replication cohorts. They concluded that this … Continue reading

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“Hyperactive intracellular calcium ion (Ca) signaling in peripheral cells has been a reliable finding in bipolar disorder. Some established mood stabilizing medications, such as lithium and carbamazepine, have been found to normalize elevated intracellular Ca concentrations ([Ca]i) in platelets and … Continue reading

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“Neurodevelopmental programming – the implementation of the genetic and epigenetic blueprints that guide and coordinate normal brain development – requires tight regulation of transcriptional processes. During prenatal and postnatal time periods, epigenetic processes fine-tune neurodevelopment towards an end product that … Continue reading

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Despite the common assumption that adult ADHD is a childhood-onset neurodevelopmental disorder, the authors of this study state that no prospective longitudinal study has described the childhoods of the adult ADHD population. Accordingly, they report follow-back analyses of ADHD cases … Continue reading

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