Monthly Archives: October 2015

“ “Man is not going to wait passively for millions of years before evolution offers him a better brain.” These words are attributed to the 20th century Romanian psychopharmacologist Corneliu Giurgea, an early advocate of cognitive enhancement—that is, the use … Continue reading

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Abstract: “Co-morbid depression and chronic pain are highly prevalent. The purpose of this review is to examine the role of chronic inflammation as a common mediator of these co-morbidities. Dysfunctional bidirectional pathways between the brain and the immune, endocrine and … Continue reading

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A number of studies have demonstrated that physical exercise can reverse cognitive decline in normal aging in both humans and rodents. It has been reported that cerebral blood volume in the dentate gyrus is increased following exercise in middle-aged humans, … Continue reading

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Motivation facilitates recovery after neuronal damage, but its mechanism is unclear. It is generally thought that the nucleus accumbens regulates motivation-driven effort but is not involved in the direct control of movement. Using causality analysis, the authors of this study … Continue reading

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“The hippocampus plays an important role in emotional and cognitive processing, and both of these domains are affected in patients with major depressive disorder (MDD). Extensive preclinical research and the notion that modulation of serotonin (5-HT) neurotransmission plays a key … Continue reading

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According to the authors of this study, treatment-resistant major depression is common and potentially life-threatening in elderly people, in whom little is known about the benefits and risks of augmentation pharmacotherapy. The purpose of this study was to assess whether … Continue reading

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