Monthly Archives: June 2014

Obesity is linked to cognitive deficits in humans, and consumption of a high-fat diet disrupts neurogenesis and neuronal function in animals. However, whether high fat intake alters sensory processing is unknown. Fadool and colleagues now show that, in mice, a … Continue reading →

Adult hippocampal neurogenesis promotes the formation of new memories, but little is known about its effect on existing memories. In this new study, Akers and colleagues demonstrate that neurogenesis — in infancy or adulthood — induces forgetting of established memories. … Continue reading →

Ketamine is an NMDA receptor antagonist that elicits rapid antidepressant responses in patients with treatment-resistant depression. However, it has adverse side effects, which has drawn clinicians to investigate whether the clinically tolerated NMDAR antagonist memantine can also elicit fast antidepressant … Continue reading →

This is an interesting commentary on the role of APOE in Alzheimer’s disease and related DNA findings. In 2009, Roses and colleagues described a stretch of non-coding DNA in a gene called TOMM40 that sits next to APOE on chromosome … Continue reading →