Monthly Archives: April 2017

“Memory-guided behavior requires maintenance of task-relevant information without sensory input, but the underlying circuit mechanism remains unclear. Calcium imaging in mice performing a delayed Go or No-Go task revealed robust delay activity in dorsomedial prefrontal cortex, with different pyramidal neurons … Continue reading

Posted in Uncategorized | Comments Off on Specific prefrontal interneuron subtypes modulate memory-guided behavior

Ageing drives changes in neuronal and cognitive function, the decline of which is a major feature of many neurological disorders. The hippocampus, a brain region subserving roles of spatial and episodic memory and learning, is sensitive to the detrimental effects … Continue reading

Posted in Uncategorized | Comments Off on Human umbilical cord plasma proteins revitalize hippocampal function in aged mice

“The First World War was a historical experiment for early-life stress. Fathers of hundreds of thousands of children of all ages were killed during the conflict. The Developmental Origins of Health and Disease hypothesis predicts long-term effects of early-life stress. … Continue reading

Posted in Uncategorized | Comments Off on Prenatal loss of father during World War One is predictive of a reduced lifespan in adulthood

Dementia is commonly encountered in advanced stages of Parkinson disease, but evidence is accumulating that cognitive decline can manifest much earlier in the disease course. Aarsland and colleagues review current knowledge regarding cognitive impairment in patients with Parkinson disease, focusing … Continue reading

Posted in Uncategorized | Comments Off on Cognitive decline in Parkinson disease