Monthly Archives: December 2023

Posted in Uncategorized | Comments Off on Remembering Professor Brian Leonard and his contributions to the Institute of Brain Medicine
Posted in Uncategorized | Comments Off on In Memory: Professor Brian Leonard 1936-2023

Abstract: Sigma-1 receptor (S1R) is a unique multi-tasking chaperone protein in the endoplasmic reticulum. Since S1R agonists exhibit potent antidepressant-like activity, S1R has become a novel target for antidepression therapy. With a rapid and sustained antidepressant effect, ketamine may also … Continue reading

Posted in Uncategorized | Comments Off on Sigma-1 receptor activation mediates the sustained antidepressant effect of ketamine in mice via increasing BDNF levels

https://www.pnas.org/topic/558 INTRODUCTIONNOVEMBER 27, 2023 The neurobiology of stress: Vulnerability, resilience, and major depression Huda Akil, Eric J. Nestler, RESEARCH ARTICLENOVEMBER 27, 2023 Transcriptional signatures of early-life stress and antidepressant treatment efficacy Sero Toriano Parel, Shannon N. Bennett, […] Catherine Jensen … Continue reading

Posted in Uncategorized | Comments Off on The Neurobiology of Stress: Vulnerability, Resilience, and Major Depression

Abstract Background: Tbr1 encodes a T-box transcription factor and is considered a high confidence autism spectrum disorder (ASD) gene. Tbr1 is expressed in the postmitotic excitatory neurons of the deep neocortical layers 5 and 6. Postnatally and neonatally, Tbr1 conditional … Continue reading

Posted in Uncategorized | Comments Off on Lithium treatment for an animal model of autism spectrum disorder

Abstract:¬†Sigma-1 receptor (SIG1R) is a chaperone that modulates inositol 1,4,5-trisphosphate receptor type1 (IP3R1) calcium (Ca2+) channels on the endoplasmic reticulum. Therefore, SIG1R functions as an indirect regulator of Ca2+ and acts as an apoptosis modulator. Increased expression of SIG1R is … Continue reading

Posted in Uncategorized | Comments Off on Blocking SIG1R Along with Low Cadmium Exposure Display Anti-cancer Qualities in Both MCF7 and MDA-MB-231 Cells