Monthly Archives: August 2015

“Down syndrome, which arises in individuals carrying an extra copy of chromosome 21, is associated with a greatly increased risk of early-onset Alzheimer disease. It is thought that this risk is conferred by the presence of three copies of the … Continue reading

Posted in Uncategorized | Comments Off on A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome

This review discusses age-related magnification of genetic effects on cognition. Heritability studies show substantial genetic influences on cognitive performance and decline in old age. Genetic influences on cognition, brain structure, and brain function were observed to become stronger as people … Continue reading

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“Cognitive decline occurs during healthy aging, even in middle-aged subjects, via mechanisms that could include reduced stem cell proliferation, changed growth factor expression and/or reduced expression of synaptic plasticity genes. Although antidepressants alter these mechanisms in young rodents, their effects … Continue reading

Posted in Uncategorized | Comments Off on Chronic antidepressant treatment and reversal of cognitive deficits in middle-aged mice: Vortioxetine-associated increase in plasticity-related gene expression

Given the huge amount of information available from the environment, how do infants know what to learn about and what to ignore? Stahl and Feigenson studied one hundred and ten 11-month-old infants and found that the children used violations of … Continue reading

Posted in Uncategorized | Comments Off on Cognitive development: Observing the unexpected enhances infants’ learning and exploration