Monthly Archives: February 2023

Epstein–Barr virus as a leading cause of multiple sclerosis: mechanisms and implications Posted on February 26, 2023 by admin

Abstract: “Epidemiological studies have provided compelling evidence that multiple sclerosis (MS) is a rare complication of infection with the Epstein–Barr virus (EBV), a herpesvirus that infects more than 90% of the global population. This link was long suspected because the … Continue reading →

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SSRIs differentially modulate the effects of pro-inflammatory stimulation on hippocampal plasticity and memory via sigma 1 receptors and neurosteroids Posted on February 19, 2023 by admin

Abstract: “Certain selective serotonin reuptake inhibitors (SSRIs) have anti-inflammatory effects in preclinical models, and recent clinical studies suggest that fluvoxamine can prevent deterioration in patients with COVID-19, possibly through activating sigma 1 receptors (S1Rs). Here we examined potential mechanisms contributing … Continue reading →

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The Role of Interferons in Long Covid Infection Posted on February 19, 2023 by admin

Abstract: “Although the new generation of vaccines and anti-COVID-19 treatment regimens facilitated the management of acute COVID-19 infections, concerns about post-COVID-19 syndrome or Long Covid are rising. This issue can increase the incidence and morbidity of diseases such as diabetes, … Continue reading →

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Environmental factors influencing the immune functions during multiple sclerosis Posted on February 18, 2023 by admin

Multiple sclerosis (MS) is a neuro-inflammatory and degenerative disease with substantial heterogeneity in presentation, clinical course, and immunopathology. In addition to genetic background, several environmental risk factors are critical mediators of the onset and course of MS (1). Disease heterogeneity … Continue reading →

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ApoE isoform– and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy Posted on February 8, 2023 by admin

The accumulation of certain forms of the tau protein in the brain is linked to loss of nerve cells, inflammation, and cognitive decline in Alzheimer’s disease and several other neurodegenerative diseases. Apolipoprotein-E (APOE), the strongest genetic risk factor for Alzheimer’s … Continue reading →

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Guillain-Barré Syndrome After COVID-19 Vaccination Posted on February 8, 2023 by admin

Abstract:   Because of historical associations between vaccines and Guillain-Barré syndrome (GBS), the condition was a prespecified adverse event of special interest for COVID-19 vaccine monitoring. To evaluate GBS reports to the Vaccine Adverse Event Reporting System (VAERS) and compare reporting … Continue reading →

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Stability of hybrid versus vaccine immunity against BA.5 infection over 8 months Posted on February 6, 2023 by admin

Introduction: “The coverage of SARS-CoV-2 vaccination in large parts of the world, together with the high number of breakthrough infections, especially following the emergence of Omicron subvariants, makes hybrid immunity (resulting from vaccine and infection) common. Hybrid immunity, particularly after … Continue reading →

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Links between COVID-19 and Parkinson’s disease/Alzheimer’s disease: reciprocal impacts, medical care strategies and underlying mechanisms Posted on February 3, 2023 by admin

Abstract: “The impact of coronavirus disease 2019 (COVID-19) pandemic on patients with neurodegenerative diseases and the specific neurological manifestations of COVID-19 have aroused great interest. However, there are still many issues of concern to be clarified. Therefore, we review the … Continue reading →

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