Monthly Archives: October 2021

Effect of early treatment with fluvoxamine on risk of emergency care and hospitalisation among patients with COVID-19 Posted on October 28, 2021 by admin

https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(21)00448-4/fulltext

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Sigma-1 Receptor: A Potential Therapeutic Target for Traumatic Brain Injury Posted on October 23, 2021 by admin

Shi M, Chen F, Chen Z, Yang W, Yue S, Zhang J, Chen X. Sigma-1 Receptor: A Potential Therapeutic Target for Traumatic Brain Injury. Front Cell Neurosci. 2021 Sep 30;15:685201. doi: 10.3389/fncel.2021.685201. PMID: 34658788; PMCID: PMC8515188. https://pubmed.ncbi.nlm.nih.gov/34658788/

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Anesthesia drugs, SARS-CoV-2, and the sigma-1 receptor: a complex affair Posted on October 17, 2021 by admin

“In conclusion, at present it is unclear whether a Sig-1R agonist or Sig-1R antagonist would be better for inhibiting SARS-CoV-2 replication. Experiments comparing these ligands in the same assay are warranted. Until then, classifying anti- inflammatory anaesthesia drugs such as … Continue reading →

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Asymptomatic SARS-CoV-2 infection: A systematic review and meta-analysis Posted on October 7, 2021 by admin

“Asymptomatic infections have been widely reported for COVID-19. However, many studies do not distinguish between the presymptomatic stage and truly asymptomatic infections. We conducted a systematic review and meta-analysis of COVID-19 literature reporting laboratory-confirmed infections to determine the burden of … Continue reading →

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Sigma-1 receptor activation alleviates blood-brain barrier disruption post cerebral ischemia stroke Posted on October 2, 2021 by admin

Abstract: “Blood-brain barrier (BBB) disruption is one of the most important pathological manifestations of ischemic stroke. Reducing BBB collapse is effective in alleviating brain parenchymal injury and cognitive dysfunction. Our previous study reported that Sigma-1 receptor (Sig-1R) activation in cerebral … Continue reading →

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The genetic symphony underlying evolution of the brain’s prefrontal cortex Posted on October 2, 2021 by admin

“The prefrontal cortex of the human brain is larger than that of other species. Comparisons of mouse, macaque and human brains uncover some of the genetic and molecular factors behind these differences….” Wallace JL and Pollen AA: The genetic symphony underlying … Continue reading →

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