Monthly Archives: November 2018

Obsessive-compulsive disorder (OCD) is associated with increased mortality, but the causes of this increase are poorly understood. This study by Isomura and colleagues examined whether OCD is associated with increased risk of metabolic and cardiovascular complications. Subjects diagnosed with OCD (n = 25,415) were identified and studied … Continue reading

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Abstract: “Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute substantially to ADHD susceptibility, but no variants have been robustly associated with ADHD. We report a … Continue reading

Posted in Uncategorized | Comments Off on Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

Dysregulation of the dopamine system is a well-established component of schizophrenia pathophysiology, with regional differences in dopamine targets thought to shape disease symptoms. Increased presynaptic striatal dopamine synthesis and release are among the most consistent findings in patients. These alterations … Continue reading

Posted in Uncategorized | Comments Off on Cortical dopamine dysregulation in schizophrenia and its link to stress

Abstract: “Heart valve disease (HVD) is a complex entity made by different pathological processes that ultimately lead to the abnormal structure and disorganization of extracellular matrix proteins resulting to dysfunction of the leaflets. At its final evolutionary step, treatments are limited … Continue reading

Posted in Uncategorized | Comments Off on Serotonin contribution to cardiac valve degeneration: new insights for novel therapies?