Monthly Archives: September 2016

Both schizophrenia and bipolar disorder are severe mental disorders associated with cognitive impairment, mood disturbance, and psychosis. Both disorders are highly heritable and share a common genetic background. The present study examines differences in genotype frequencies of polymorphisms located in … Continue reading

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“Proinflammatory conditions, including acute and chronic infections, have been associated with an increased risk of stroke. The risk of stroke is increased by both the acute and chronic phases of a wide spectrum of proinflammatory conditions, suggesting that the association … Continue reading

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Bipolar disorder is associated with mood episodes and low amplitude circadian rhythms. Fibroblasts from bipolar disorder patients have also previously been shown to have weaker lithium-induced amplification of circadian rhythms compared to control cells. Since calcium signals impact upon the … Continue reading

Posted in Uncategorized | Comments Off on Calcium channel genes associated with bipolar disorder modulate lithium action

Patients with bipolar disorder have a high prevalence of comorbid medical illness. However, the mechanisms underlying these comorbidities with bipolar disorder are not well known. Certain genetic variants may have pleiotropic effects, increasing the risk of bipolar disorder and other … Continue reading

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While endurance exercise training improves cerebrovascular health and has neurotrophic effects within the hippocampus, the effects of stopping this exercise on the brain remain unclear. The aim of this study was to measure the effects of 10 days of detraining … Continue reading

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Serotonin (5-HT) is a neurotransmitter that has an essential role in the regulation of emotion but the precise circuits regulating aversive states have not yet been clearly defined. Here the authors “show that 5-HT from the dorsal raphe nucleus (5-HTDRN) … Continue reading

Posted in Uncategorized | Comments Off on Serotonin→CRF circuitry: possible role in early adverse events to SSRIs in anxiety disorder