Monthly Archives: August 2024

HYPOTHESIS AND THEORY article Yamakawa H., et al.:  Front. Syst. Neurosci., 19 August 2024 Volume 18 – 2024 | https://doi.org/10.3389/fnsys.2024.1302429 Abstract: Background: “Imagination represents a pivotal capability of human intelligence. To develop human-like artificial intelligence, uncovering the computational architecture pertinent to … Continue reading →

Abstract:   “Animal personality, consistent individual differences in behaviour, is an important concept for understanding how individuals vary in how they cope with environmental challenges. In order to understand the evolutionary significance of animal personality, it is crucial to understand … Continue reading →

For Discussion: Is Epigenetics the best way to alter your personality? https://developingchild.harvard.edu/resources/what-is-epigenetics-and-how-does-it-relate-to-child-development/

Abstract: “Lactate is a critical metabolite during the body’s adaption to exercise training, which effectively relieves anxiety-like disorders. The biological mechanism of lactate in the exercise-mediated anxiolytic effect has, however, not been comprehensively investigated. Here, we report that exercise-induced lactate … Continue reading →

https://www.cell.com/cell/fulltext/S0092-8674(24)00702-5

McCutcheon SR, Rohm D, Iglesias N, Gersbach CA. Epigenome editing technologies for discovery and medicine. Nat Biotechnol. 2024 Aug;42(8):1199-1217. doi: 10.1038/s41587-024-02320-1. Epub 2024 Jul 29. PMID: 39075148. https://pubmed.ncbi.nlm.nih.gov/39075148/  

“Reactive microglia contribute to Parkinson’s disease (PD) pathogenesis. Certain cytokines such as interleukin-10 (IL-10) can restore microglia homeostasis, but targeting maladaptive immune responses without inducing systemic side effects remains a challenge. Bido et al. adopted a microRNA-detargeting system that inhibits … Continue reading →

Abstract:  Lactate, a byproduct of glycolysis, was considered as a metabolic waste until identified by studies on the Warburg effect. Increasing evidence elucidates that lactate functions as energy fuel, signaling molecule, and donor for protein lactylation. Altered lactate utilization is … Continue reading →

Abbreviated article…     “We’re now in the midst of a multistate outbreak of influenza A H5N1 bird flu in dairy cows and other animals. USDA has confirmed outbreaks in more than 130 dairy herds across 12 states, and also … Continue reading →

Dementia prevention, intervention, and care 2024 Published: July 31, 2024 Executive Summary As life expectancies increase, the number of people living with dementia worldwide continues to rise. The 2024 report of the Lancet Commission on dementia prevention, intervention, and care … Continue reading →