Monthly Archives: May 2019

Abstract: “Multiple sclerosis (MS) is characterized by inflammatory insults that drive neuroaxonal injury. However, knowledge about neuron-intrinsic responses to inflammation is limited. By leveraging neuron-specific messenger RNA profiling, we found that neuroinflammation leads to induction and toxic accumulation of the synaptic … Continue reading

Posted in Uncategorized | Comments Off on Bassoon proteinopathy drives neurodegeneration in multiple sclerosis

Abstract:  “Mental health and well-being are consistently influenced-directly or indirectly-by multiple environmental exposures. In this review, we have attempted to address some of the most common exposures of the biophysical environment, with a goal of demonstrating how those factors interact … Continue reading

Posted in Uncategorized | Comments Off on Environmental Exposures and Depression: Biological Mechanisms and Epidemiological Evidence

Abstract: “Memory is coded by patterns of neural activity in distinct circuits. Therefore, it should be possible to reverse engineer a memory by artificially creating these patterns of activity in the absence of a sensory experience. In olfactory conditioning, an … Continue reading

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Abstract: “The neurobiological mechanisms underlying the induction and remission of depressive episodes over time are not well understood. Through repeated longitudinal imaging of medial prefrontal microcircuits in the living brain, we found that prefrontal spinogenesis plays a critical role in … Continue reading

Posted in Uncategorized | Comments Off on Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation

Abbreviated abstract: Children learn language more easily than adults, though when and why this ability declines have been obscure for a number of reasons. Studying a very large number of subjects, the authors  provide the first direct estimate of how grammar-learning ability … Continue reading

Posted in Uncategorized | Comments Off on A critical period for second language acquisition: Evidence from 2/3 million English speakers