Monthly Archives: December 2011

Obsessive-compulsive disorder (OCD) is a severe condition for which there is evidence that genetic factors may affect drug treatment response. Between 40 and 60% of OCD patients are considered to be nonresponders to antidepressant treatment. Identification of biological factors affecting … Continue reading →

L-DOPA therapy is well known to induce the side effect of dyskinesia in Parkinson’s disease patients. The biochemical pathways for this involve activation of rapamycin (mTOR) signaling in the striatum. The authors of this study found that Ras homolog enriched … Continue reading →

Early brain overgrowth is often a feature of autism, but the cellular defects that cause abnormal overgrowth are not known. To investigate whether increased numbers of neurons are responsible, the authors examined postmortem brain tissue from children aged 2 to … Continue reading →

The authors of this study were keen to note that combined antidepressant and psychotherapy treatments are more effective in treating mood disorders than either treatment alone. To investigate how antidepressants influence such behavioral response to emotional experience, they conducted a … Continue reading →