Monthly Archives: January 2016

Cognitive dysfunction in major depressive disorder (MDD) encompasses several domains, including but not limited to executive function, verbal memory, and attention. It is a frequent residual manifestation in depression and may persist during the remitted phase. The authors of this … Continue reading →

“Molecular, genetic and pathological evidence suggests that deficits in GABAergic parvalbumin-positive interneurons contribute to schizophrenia pathophysiology through alterations in the brain’s excitation-inhibition balance that result in impaired behaviour and cognition. Although the factors that trigger these deficits are diverse, there … Continue reading →

In this study, Barch and colleagues tested the hypothesis that poverty experienced in early childhood, as measured by income-to-needs ratio, has an impact on functional brain connectivity at school age, which in turn influences child negative mood/depression. Preschoolers 3-5 years … Continue reading →

Preclinical studies show that the multimodal antidepressant vortioxetine enhances long-term potentiation and dendritic branching compared to a selective serotonin reuptake inhibitor (SSRI). Here, Chen and colleagues investigated vortioxetine׳s effects on spines and dendritic morphology in rat hippocampus compared to the … Continue reading →

In this study, Rosenberg and colleagues identified functional brain networks whose strength in a sustained attention task predicted individual differences in performance. Using functional magnetic resonance imaging, the models predicted a clinical measure of attention, namely symptoms of attention deficit … Continue reading →

Ants are insects which organize themselves into behavioral castes whose regulation has been proposed to involve epigenetic processes, including histone modification. In the carpenter ant, morphologically distinct worker castes called minors and majors exhibit pronounced differences in foraging and scouting/exploratory … Continue reading →

“Identifying cognitive and neural mechanisms involved in the development of schizophrenia requires longitudinal observation of individuals prior to onset. Here recent studies of prodromal individuals who progress to full psychosis are briefly reviewed in relation to models of schizophrenia pathophysiology. … Continue reading →