Monthly Archives: February 2020

Article excerpt:  “Nearly every scientist who has used mice or rats to study depression is familiar with the forced-swim test. The animal is dropped into a tank of water while researchers watch to see how long it tries to stay … Continue reading

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Davidsohn N, Pezone M, Vernet A, Graveline A, Oliver D, Slomovic S, Punthambaker S, Sun X, Liao R, Bonventre JV, and  Church GM: A single combination gene therapy treats multiple age-related diseases, Proc. Natl. Acad. Sci. USA  116 (47): 23505-23511 (2019). https://www.pnas.org/content/pnas/116/47/23505.full.pdf

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Abstract: “Dopaminergic and serotonergic neurons modulate and control processes ranging from reward signaling to regulation of motor outputs. Further, dysfunction of these neurons is involved in both degenerative and psychiatric disorders. Elucidating the roles of these neurons has been greatly … Continue reading

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Summary: “Ketamine, an NMDA receptor antagonist, has generated intense excitement as a therapy for treatment-resistant depression. However, ketamine and its metabolites can act on a wide range of targets, including opioid receptors, which has raised concerns. Using behavioral and cellular … Continue reading

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Summary: “The influence of migration on disease risk has long been an important consideration in multiple sclerosis (MS) epidemiological research. Taking advantage of recent methodological advances, including access to population-based administrative health data, a new study highlights the importance of country of origin … Continue reading

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