Monthly Archives: April 2013

The human brain shrinks with advancing age, but recent research suggests that it is also capable of remarkable plasticity, even in late life. In this review the authors summarize the research linking greater amounts of physical activity to less cortical … Continue reading →

Relative amounts of amyloid-β peptides of different lengths are altered in the brains of Alzheimer’s disease patients. In this report, Dolev and colleagues show that neuronal activity patterns differentially regulate the production of amyloid-β isoforms by modifying the molecular conformation … Continue reading →

To investigate risk factors for Amyloid-beta deposition in cognitively healthy middle-aged and older adults, the authors studied individuals with hypertension, in combination with the APOE4 genetic risk factor for Alzheimer’s disease. 118 cognitively normal adults, aged 47 to 89 years … Continue reading →

Evidence suggests that participation in contact–collision sports may increase the risk of neurodegenerative disorders such as Alzheimer’s disease. In this review, sports-related traumatic brain injury (TBI) is discussed as well as advances in our understanding of the pathology of brain … Continue reading →

Human studies suggest that deficits in prefrontal cortical function and the resulting loss of inhibitory control could be crucial in promoting compulsive drug use. However, it is unclear whether chronic drug use compromises cortical activity and whether this deficit promotes … Continue reading →

The estimated prevalence of dementia among persons older than 70 years of age in the United States was 14.7% in 2010. In this study, 856 individuals from the Health and Retirement Study in the USA (total 10,903 subjects) were assessed … Continue reading →

Alzheimer’s disease develops slowly from a preclinical phase into a fully expressed clinical syndrome. The present study used longitudinal data to calculate the rates of amyloid-beta (Aβ) deposition, cerebral atrophy, and cognitive decline. In this prospective cohort study, 145 healthy … Continue reading →