Monthly Archives: December 2018

Major Depressive Disorder: Cognitive Assessment in First-Degree Relatives Posted on December 28, 2018 by admin

Cognitive impairment in major depressive disorder (MDD), including remitted major depressive disorder, raises the question whether these cognitive defects are part of preexisting vulnerability or a consequence of the disorder or its treatment. The purpose of this study was to compare (via meta-analysis) … Continue reading →

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Nature’s 10: Ten people who mattered this year. Posted on December 23, 2018 by admin

https://www.nature.com/immersive/d41586-018-07683-5/index.html

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Ancestral origin of ApoE ε4 Alzheimer disease risk in populations Posted on December 20, 2018 by admin

“The ApoE ε4 allele is the most significant genetic risk factor for late-onset Alzheimer disease. The risk conferred by ε4, however, differs across populations, with populations of African ancestry showing lower ε4 risk compared to those of European or Asian ancestry. The … Continue reading →

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Revealing the brain’s molecular architecture Posted on December 14, 2018 by admin

Revealing the brain’s molecular architecture The PsychENCODE Consortium Science  14 Dec 2018: Vol. 362, Issue 6420, pp. 1262-1263 DOI: 10.1126/science.362.6420.1262 http://science.sciencemag.org/content/362/6420/1262/tab-pdf BRAIN_DEC_2018issue    

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Chemobrain: Glial cells help cancer drugs to cloud the mind Posted on December 12, 2018 by admin

The following report describes how microglia in the brain might have a role in the cognitive impairment (“chemobrain”) seen after chemotherapy cancer treatment. “…Some chemotherapies cause a lasting condition known as ‘chemobrain’, which is marked by deficiencies in attention, information … Continue reading →

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City Living and Psychotic Disorders—Implications of Global Heterogeneity for Theory Development Posted on December 9, 2018 by admin

Excerpts from article: “The observation that higher rates of schizophrenia and other nonaffective psychotic disorders are associated with city living is robustly replicated across epidemiologic studies conducted throughout Northern Europe and North America. The weight of this evidence, combined with exhaustive … Continue reading →

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Treatment-resistant and multi-therapy-resistant criteria for bipolar depression: consensus definition Posted on December 8, 2018 by admin

Abstract:  “Most people with bipolar disorder spend a significant percentage of their lifetime experiencing either subsyndromal depressive symptoms or major depressive episodes, which contribute greatly to the high levels of disability and mortality associated with the disorder. Despite the importance of bipolar depression, there are … Continue reading →

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The past, present and future of light-gated ion channels and optogenetics Posted on December 1, 2018 by admin

Abstract: “The discovery of the mechanisms underlying light-gated ion channels called channel rhodospins and the subsequent development of optogenetics illustrates how breakthroughs in science and technology can span multiple levels of scientific inquiry. Our knowledge of how channelrhodopsins work emerged … Continue reading →

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