Monthly Archives: July 2015

“Development of the cerebral cortex is influenced by sensory experience during distinct phases of postnatal development known as critical periods. Disruption of experience during a critical period produces neurons that lack specificity for particular stimulus features, such as location in … Continue reading

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Migraine is a complex multifactorial, neurobiological disorder. A possible role of impaired oxidative mitochondrial metabolism in migraine pathogenesis has been hypothesized. The aim of this study was to determine plasma levels of advanced oxidation protein products, ferric-reducing antioxidant power and … Continue reading

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Adversity, particularly in early life, can be associated with later illness. Clues to the responsible mechanisms may lie with the discovery of molecular signatures of stress, some of which include alterations to an individual’s somatic genome. Here, Cai and colleagues … Continue reading

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The purpose of this study was to assess the risk of intracranial haemorrhage among patients treated with antidepressants and non-steroidal anti-inflammatory drugs (NSAIDs), compared with the risk among those treated with antidepressants without NSAIDs. This was a retrospective nationwide propensity … Continue reading

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Ketamine produces rapid antidepressant action in depressed patients, but the precise cellular mechanisms underlying these effects have not been identified. Here Fuchikami and colleagues studied if modulation of neuronal activity in the infralimbic prefrontal cortex underlies the antidepressant and anxiolytic … Continue reading

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Huntington’s disease is a genetically based, severe neurodegenerative disorder that results in progressive motor, cognitive and psychiatric impairment and, ultimately, death. It is caused by an expanded CAG triplet repeat producing a mutant huntingtin protein with a polyglutamine-repeat expansion. There … Continue reading

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