Monthly Archives: May 2024

Reliable execution of precise behaviors requires that brain circuits are resilient to variations in neuronal dynamics. Genetic perturbation of the majority of excitatory neurons in HVC, a brain region involved in song production, in adult songbirds with stereotypical songs triggered … Continue reading →

https://www.nature.com/articles/d41586-024-01387-9 Researchers have mapped a tiny piece of the human brain in astonishing detail. The resulting cell atlas, which was described in Science and is available online, reveals new patterns of connections between brain neurons, as well as cells that wrap … Continue reading →

Multiple sclerosis (MS) is a global health concern affecting around 2.6 million people. It is characterised by neural inflammation, myelin breakdown and cognitive decline. Cognitive impairment, especially reduced cognitive processing speed (CPS), which affects up to 67% of MS patients … Continue reading →

SCH23390 is a widely used D1 dopamine receptor (D1R) antagonist that also elicits some D1R-independent effects. We previously found that the benzazepine, SKF83959, an analog of SCH23390, produces positive allosteric modulation of the Sigma-1 receptor (Sig1R). SCH23390 does not bind … Continue reading →