Although understanding of the biological mechanisms of stroke have advanced considerably in animal models, this progress has not been translated into improvements to restorative therapies following stroke in humans. In this review, Ward discusses the reasons behind this lack of benefit, and the prospects for understanding post stroke plasticity in humans, with a focus on the development of biomarkers that can reconcile preclinical and human studies.
.Ward NS: Restoring brain function after stroke – bridging the gap between animals and humans. Nature Reviews Neurology [Epub ahead of print, Mar. 17, 2017; doi: 10.1038/nrneurol.2017.34.]