“Reactive microglia contribute to Parkinson’s disease (PD) pathogenesis. Certain cytokines such as interleukin-10 (IL-10) can restore microglia homeostasis, but targeting maladaptive immune responses without inducing systemic side effects remains a challenge. Bido et al. adopted a microRNA-detargeting system that inhibits the expression of a transgene in all but the cell type of choice. Using this system for lentiviral-mediated, local, and microglia-specific expression of IL-10 in PD mice led to reduced neuropathology and the emergence of microglial subtypes with enhanced clearance signatures. These results suggest the therapeutic potential of cell type–specific gene delivery for PD. ”

Bido S et al.: Microglia-specific IL-10 gene delivery inhibits neuroinflammation and neurodegeneration in a mouse model of Parkinson’s disease. Science Translational Medicine 16 (761), (21 Aug 2024).

https://www.science.org/doi/10.1126/scitranslmed.adm8563