As life expectancies increase, the number of people living with dementia worldwide continues to rise. The 2024 report of the Lancet Commission on dementia prevention, intervention, and care adds compelling new evidence that untreated vision loss and high LDL cholesterol are risk factors for dementia. Overall, around 45% of cases of dementia are potentially preventable by addressing 14 modifiable risk factors at different stages during the life course.

The 2024 Commission update also provides updates on advances in fluid biomarkers for detection of Alzheimer’s disease, new definitions for diagnosis of Alzheimer’s disease, as well as progress on disease-modifying treatments.