The purpose of this study was to assess the risk of intracranial haemorrhage among patients treated with antidepressants and non-steroidal anti-inflammatory drugs (NSAIDs), compared with the risk among those treated with antidepressants without NSAIDs. This was a retrospective nationwide propensity score matched cohort study with subjects from the Korean nationwide health insurance database between the dates of 1 January 2009 and 31 December 2013. After propensity score estimation and matching in a 1:1 ratio, the cohort used in the analysis included 4,145,226 subjects. Time to first hospital admission with intracranial haemorrhage within 30 days after drug use was recorded.
The authors found that the 30 day risk of intracranial haemorrhage during the entire study period was higher for combined use of antidepressants and NSAIDs than for use of antidepressants without NSAIDs. No significant differences were found between antidepressant drug classes for risk of intracranial haemorrhage. The report concluded that the combined use of antidepressants and NSAIDs was associated with an increased risk of intracranial haemorrhage within 30 days of initial combination.
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Shin J-Y, Park, M-J, Lee SH, Choi S-H, Kim M-H, Choi N-K, Lee J, Park B-J: Risk of intracranial haemorrhage in antidepressant users with concurrent use of non-steroidal anti-inflammatory drugs: nationwide propensity score matched study. BMJ 351: h3517 (2015).
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http://www.bmj.com/content/351/bmj.h3517?ijkey=b74a8cce14a7eb0d442ba88d8f0f54f6b712a686&keytype2=tf_ipsecsha