Migraine is a complex multifactorial, neurobiological disorder. A possible role of impaired oxidative mitochondrial metabolism in migraine pathogenesis has been hypothesized. The aim of this study was to determine plasma levels of advanced oxidation protein products, ferric-reducing antioxidant power and total thiol groups related to oxidative stress, in a sample of chronic migraine patients and medication-overuse headache, compared to healthy control subjects.
Thirty-three patients with a diagnosis of both chronic migraine and medication-overuse headache (International Classification of Headache Disorders,3rd edition, beta version) and 33 healthy, headache-free subjects were studied. Patients with comorbid/coexisting conditions were excluded, as well as patients in treatment with migraine preventive drugs. Plasma levels of advanced oxidation protein products, ferric-reducing antioxidant power, and total thiol groups were determined in migraine patients and controls. Oxidative stress biomarkers were compared in migraine patients with triptan compared to non-steroidal anti-inflammatory drug overuse.
The data from the present study suggest that antioxidant capacity is lower in chronic migraine patients and medication-overuse headache compared to healthy headache-free subjects, with no differences between patients with triptan or nonsteroidal anti-inflammatory drug overuse. Further research is needed regarding the causal or consequential role of an imbalance between pro-oxidants and antioxidant defenses in migraine pathogenesis and the possible therapeutic implications in clinical practice.
Lucchesi C, Baldacci F, Cafalli M, Chico L, Lo Gerfo A, Bonuccelli U, Siciliano G, Gori S: Evidences of Reduced Antioxidant Activity in Patients With Chronic Migraine and Medication-Overuse Headache. Headache 55(7): 984-991 (2015).

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