Category Archives: Uncategorized

Covid-19 related stroke: No preventative value of antithrombotic therapy Posted on November 21, 2021 by admin

Abbreviated Highlights: In several previously published studies, the incidence of Acute Ischemic Stroke ranged from 0.9% to 2.7% in those with COVID-19, …  One of the studies calculated a more than sevenfold greater risk of Acute Ischemic Stroke among patients … Continue reading →

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Rapid response to selective serotonin reuptake inhibitors in post-COVID depression Posted on November 17, 2021 by admin

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500775/

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In vitro and in vivo sigma 1 receptor imaging studies in different disease states Posted on November 15, 2021 by admin

Agha H, McCurdy CR. In vitro and in vivo sigma 1 receptor imaging studies in different disease states. RSC Med Chem. 2021 Oct 8;12(2):154-177. doi: 10.1039/d0md00186d. PMID: 34046607; PMCID: PMC8127618. https://pubmed.ncbi.nlm.nih.gov/34046607/

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Association of Alopecia Areata with increased Risk of Dementia Posted on November 6, 2021 by admin

Alopecia areata (AA) is an autoimmune disorder that usually results in unpredictable, patchy hair loss. It is associated with multiple comorbidities and shares a similar inflammatory signature with dementia. The great negative psychosocial impact of AA may result in poor … Continue reading →

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Brain-derived neurotrophic factor for high-throughput evaluation of selective Sigma-1 receptor ligands Posted on November 4, 2021 by admin

Abstract:  “The Sigma-1 receptor (S1R) is an endoplasmic reticulum (ER) chaperone protein that has been implicated in attenuating inflammatory stress-mediated brain injuries. Selective S1R agonists represent a new class of therapeutic agent for treating neuropsychiatric and neurodegenerative disorders, however, to … Continue reading →

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Effect of early treatment with fluvoxamine on risk of emergency care and hospitalisation among patients with COVID-19 Posted on October 28, 2021 by admin

https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(21)00448-4/fulltext

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Sigma-1 Receptor: A Potential Therapeutic Target for Traumatic Brain Injury Posted on October 23, 2021 by admin

Shi M, Chen F, Chen Z, Yang W, Yue S, Zhang J, Chen X. Sigma-1 Receptor: A Potential Therapeutic Target for Traumatic Brain Injury. Front Cell Neurosci. 2021 Sep 30;15:685201. doi: 10.3389/fncel.2021.685201. PMID: 34658788; PMCID: PMC8515188. https://pubmed.ncbi.nlm.nih.gov/34658788/

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Anesthesia drugs, SARS-CoV-2, and the sigma-1 receptor: a complex affair Posted on October 17, 2021 by admin

“In conclusion, at present it is unclear whether a Sig-1R agonist or Sig-1R antagonist would be better for inhibiting SARS-CoV-2 replication. Experiments comparing these ligands in the same assay are warranted. Until then, classifying anti- inflammatory anaesthesia drugs such as … Continue reading →

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Asymptomatic SARS-CoV-2 infection: A systematic review and meta-analysis Posted on October 7, 2021 by admin

“Asymptomatic infections have been widely reported for COVID-19. However, many studies do not distinguish between the presymptomatic stage and truly asymptomatic infections. We conducted a systematic review and meta-analysis of COVID-19 literature reporting laboratory-confirmed infections to determine the burden of … Continue reading →

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Sigma-1 receptor activation alleviates blood-brain barrier disruption post cerebral ischemia stroke Posted on October 2, 2021 by admin

Abstract: “Blood-brain barrier (BBB) disruption is one of the most important pathological manifestations of ischemic stroke. Reducing BBB collapse is effective in alleviating brain parenchymal injury and cognitive dysfunction. Our previous study reported that Sigma-1 receptor (Sig-1R) activation in cerebral … Continue reading →

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