“In conclusion, at present it is unclear whether a Sig-1R agonist or Sig-1R antagonist would be better for inhibiting SARS-CoV-2 replication. Experiments comparing these ligands in the same assay are warranted. Until then, classifying anti- inflammatory anaesthesia drugs such as dexmedetomidine21 as ‘pro-viral’ based on their agonistic activity on Sig-1R is not supported by evidence.”

Jain A, Lamperti M, Doyle DJ, Lobo FA. Anaesthesia drugs, SARS-CoV-2, and the sigma-1 receptor: a complex affair. Comment on Br J Anaesth 2021; 127: e32-4. Br J Anaesth. 2021 Sep 20:S0007-0912(21)00579-1. doi: 10.1016/j.bja.2021.09.008. Epub ahead of print. PMID: 34635287; PMCID: PMC8500736.

https://pubmed.ncbi.nlm.nih.gov/34635287/

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