In several previously published studies, the incidence of Acute Ischemic Stroke ranged from 0.9% to 2.7% in those with COVID-19, …
One of the studies calculated a more than sevenfold greater risk of Acute Ischemic Stroke among patients with COVID-19 compared with patients with influenza…
… three mechanisms that may be contributing to the increased risk for Acute Ischemic Stroke accompanying COVID-19: binding of the virus to the ACE2 receptor on blood vessel walls causing vasculitis, cardioembolism, or paradoxical embolism, and the well-known hypercoagulability state that occurs with COVID-19.
The authors reasoned that if cardioembolism or paradoxical embolism were the cause of the strokes, anticoagulation should have a preventive effect. If platelet hyperaggregability played a role, antiplatelet agents could be beneficial.
The aim of the study was to investigate the role of thromboprophylaxis in the primary prevention of cerebrovascular events among patients with COVID-19. The conclusions of the study were that anticoagulation and/or antiplatelet therapy with a variety of agents did not prevent acute ischemic stroke in elderly patients with COVID-19 and comorbidities.
Di Pietro M et al., Covid-19 related stroke: No preventative value of antithrombotic therapy. Journal of the Neurological Sciences 429, Supplement: 117659, October 1, 2021. DOI:https://doi.org/10.1016/j.jns.2021.117659
https://www.jns-journal.com/article/S0022-510X(21)00353-1/fulltext
https://www.medscape.com/viewarticle/961323