Abbreviated Abstract:  Super antigens are some part of virus or bacteria proteins which stimulate T cells and antigen-presenting cells leading to systemic immune response and inflammation. Super antigens have a possible role in in various inflammatory childhood diseases (i.e. Kawasaki disease, atopic dermatitis, and chronic rhinosinusitis). Occasionally, clinical presentations of some human viruses (eg coronavirus and adenovirus) mimic Kawasaki disease. In addition, coinfection with adenovirus, coronavirus, and para-influenza virus type 3 were observed with Kawasaki disease. This study summarizes the relationship between viral and bacterial super antigens and childhood inflammatory diseases.

Noorbakhsh S, Ashouri S, Moradkhani M. Role of Superantigens In Various Childhood Inflamatory Diseases. Infect Disord Drug Targets. 2022 May 30. doi: 10.2174/1871526522666220530141031. Epub ahead of print. PMID: 35638540.

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