Obsessive-compulsive disorder (OCD) is a severe condition for which there is evidence that genetic factors may affect drug treatment response. Between 40 and 60% of OCD patients are considered to be nonresponders to antidepressant treatment. Identification of biological factors affecting treatment response may aid improvement of clinical outcome. In this article, the authors review the scientific literature on clinical and demographical factors associated with drug response in OCD. They then discuss candidate genes which may influence drug response, including those involved in the serotonin pathways, brain-derived neurotrophic factor and the glutamate transporter gene. The cytochrome system is also discussed with regard to drug treatment response.

Brandl EJ, Müller DJ, Richter MA: Pharmacogenetics of obsessive-compulsive disorders. Pharmacogenomics 13(1):71-81 (2012).

http://www.ncbi.nlm.nih.gov/pubmed/22176623